{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:48:12Z","timestamp":1772160492281,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T00:00:00Z","timestamp":1156982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    Quantitative relationships between immunological reactivity, non\u2010specific bronchial responsiveness and bronchial responsiveness to allergens have scarcely been investigated in occupational asthma.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:\u2002<\/jats:bold>\n                    We assessed the above relationships in 24 subjects with baker's asthma. The skin endpoint titration to bakery allergens as a measure of immunological reactivity, together with the methacholine PC\n                    <jats:sub>20<\/jats:sub>\n                    and allergen PC\n                    <jats:sub>20<\/jats:sub>\n                    during early asthmatic reaction were determined.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    All patients had positive skin tests to some bakery allergens (wheat and rye flour, soybean flour, fungal enzymes and egg white proteins) and bronchial hyperresponsiveness to methacholine. Specific inhalation challenge (SIC) tests were performed with aqueous allergen extracts of cereal flour (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200314), soybean (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u20038), baking enzymes (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200312), and egg white proteins (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u20038) in sensitized workers. A positive asthmatic reaction was observed in 84% of the inhalation challenges. SIC elicited isolated early asthmatic reactions in 62%, dual reactions in 32% and isolated late reactions in 5%. Multiple linear regression analysis showed allergen PC\n                    <jats:sub>20<\/jats:sub>\n                    as a function of skin sensitivity to allergen and methacholine PC\n                    <jats:sub>20<\/jats:sub>\n                    , yielding the following highly significant regression formula: log\u2010allergen PC\n                    <jats:sub>20<\/jats:sub>\n                    \u2003=\u20030.18\u2003+\u20030.99 log(skin sensitivity)\u2003+\u20030.343 log(methacholine PC\n                    <jats:sub>20<\/jats:sub>\n                    ) (\n                    <jats:italic>r<\/jats:italic>\n                    \u2003=\u20030.89,\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.001). This formula predicted allergen PC\n                    <jats:sub>20<\/jats:sub>\n                    to within one double concentration in 67%, to within two double concentrations in 85% and within three double concentrations in 97%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    The main determinant of bronchial responsiveness to allergen in patients with baker's asthma is the degree of sensitization to occupational allergens as determined by skin reactivity, modulated to a lesser extent by non\u2010specific bronchial hyperresponsiveness.\n                  <\/jats:p>","DOI":"10.1111\/j.1398-9995.2006.01189.x","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T05:58:00Z","timestamp":1157003880000},"page":"1202-1208","source":"Crossref","is-referenced-by-count":33,"title":["Bronchial responsiveness to bakery\u2010derived allergens is strongly dependent on specific skin sensitivity"],"prefix":"10.1111","volume":"61","author":[{"given":"S.","family":"Quirce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fern\u00e1ndez\u2010Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Escudero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cuesta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"De Las Heras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sastre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,31]]},"reference":[{"issue":"5","key":"e_1_2_6_2_2","first-page":"187","article-title":"Hypersensibilit\u00e9 cholinergico\u2010histaminique pulmonaire de l'asthmatique: relation avec l'hypersensibilit\u00e9 allerg\u00e9nique pulmonaire","volume":"13","author":"Tiffenau R","year":"1958","journal-title":"Acta Allergol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1975.tb01847.x"},{"key":"e_1_2_6_4_2","first-page":"1053","article-title":"Determinants of allergen\u2010induced asthma: dose of allergen, circulating IgE antibody concentration, and bronchial responsiveness to inhaled histamine","volume":"120","author":"Cockcroft DW","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_6_5_2","first-page":"264","article-title":"Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine","volume":"135","author":"Cockcroft DW","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00612.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01744.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116432"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90470-M"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1977.tb01448.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.4.505"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.053s1693"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF02914442","article-title":"Specific bronchoprovocation testing","volume":"8","author":"Chan\u2010Yeung M","year":"1990","journal-title":"Clin Rev Allergy"},{"key":"e_1_2_6_14_2","first-page":"211","volume-title":"Asthma in the workplace","author":"Cartier A","year":"1999"},{"issue":"35","key":"e_1_2_6_15_2","first-page":"1","article-title":"EAACI provocation tests with allergens. 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