{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T14:18:41Z","timestamp":1770387521735,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Nasal polyps (NP), a subgroup of chronic rhinosinusitis, are characterized by interleukin 5 (IL\u20105) mediated infiltration of eosinophils in sinus mucosa, leading to pseudostratified ciliated columnar epithelium, thickening of the epithelial basement membrane and tissue edema. Matrix metalloproteinases (MMP) constitute a large group of Zn<jats:sup>2+<\/jats:sup> dependent endopeptidases with the ability to degrade extracellular matrix and are possibly responsible for the development of tissue edema in chronic sinusitis.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> The aim of this study was to determine the expression of MMP\u20102, MMP\u20109 and tissue inhibitor of matrix metalloproteinase\u20101 (TIMP\u20101) mRNA and to locate the distribution of MMP\u20102, MMP\u20109 and TIMP\u20101 by immunohistochemistry in ethmoid sinus mucosa in NP. Furthermore the correlation between IL\u20105 or IL\u20108 and MMP\u20102, MMP\u20109 or TIMP\u20101 is examined.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Nasal polyps of 33 patients and 18 specimens of inferior turbinate mucosa were examined by real time RT\u2010PCR for MMP\u20102, MMP\u20109, TIMP\u20101, IL\u20105 and IL\u20108 mRNA expression. Immunohistochemical labeling for MMP\u20102, MMP\u20109 and TIMP\u20101 was performed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Differences between both locations were detectable for MMP\u20109 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and IL\u20105 (<jats:italic>P<\/jats:italic>\u2003=\u20030.003) but not for MMP\u20102 (<jats:italic>P<\/jats:italic>\u2003=\u20030.278), TIMP\u20101 (<jats:italic>P<\/jats:italic>\u2003=\u20030.515) and IL\u20108 (<jats:italic>P<\/jats:italic>\u2003=\u20030.386). Correlation was detected only between TIMP\u20101 and IL\u20105 (<jats:italic>r<\/jats:italic>\u2003=\u20030.422, <jats:italic>P<\/jats:italic>\u2003=\u20030.014). Cytoplasmic staining of MMP\u20102 was present in the apical part of the ciliated cells, submucosal glands and in smooth muscle cells. Matrix metalloproteinase\u20109 was expressed in surface epithelium, in seromucous glands and in polymorphonuclear cells.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Expression of MMP\u20109 and IL\u20105 mRNA are associated with NP. The correlation between IL\u20105 and TIMP\u20101 indicates the role of TIMP\u20101 in maintaining the homeostasis in NP.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2006.01255.x","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T10:09:24Z","timestamp":1165399764000},"page":"66-72","source":"Crossref","is-referenced-by-count":57,"title":["Relationship between matrix metalloproteinases MMP\u20102, MMP\u20109, tissue inhibitor of matrix metalloproteinases\u20101 and IL\u20105, IL\u20108 in nasal polyps"],"prefix":"10.1111","volume":"62","author":[{"given":"Y.\u2010S.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Langhammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Westhofen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lorenzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,6]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps","volume":"18","author":"European Academy of Allergology and Clinical Immunology","year":"2005","journal-title":"Rhinol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200204000-00026"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)80019-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2500\/105065898780708008"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2500\/105065899781367546"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00835.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-002-0088-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00110.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900202"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/000164800454314"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90944-X"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389203023380549"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.100448997"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000053598"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2003.18.1.97"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410017152"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00364.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH771>3.0.CO;2-W"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150674.30237.3f"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119024"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1757"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3369"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.1999.14.465"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.11.691"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006749304315"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199602)166:2<413::AID-JCP20>3.0.CO;2-A"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70100-8"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.17.4.2877"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80015-9"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90140-5"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.9808087"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(90)92165-V"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(98)70209-8"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161334.67977.5D"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1004612"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00028.x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2006.01255.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2006.01255.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:36:55Z","timestamp":1696883815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2006.01255.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,6]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1398-9995.2006.01255.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2006.01255.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,6]]}}}