{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:34:37Z","timestamp":1791200077200,"version":"4.2.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Allergic reactions to <jats:italic>\u03b2<\/jats:italic>\u2010lactams are the most frequent cause of adverse drug reactions mediated by specific immunologic mechanisms. They can be explored by <jats:italic>in vivo<\/jats:italic> and\/or <jats:italic>in vitro<\/jats:italic> tests. The measurement of serum\u2010specific immunoglobulin E (IgE) presents several advantages: safety, simplicity, and availability to nonallergologist physicians.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To establish the diagnostic value of specific IgE determination in the diagnosis procedure of immediate <jats:italic>\u03b2<\/jats:italic>\u2010lactam allergy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The <jats:italic>in vitro<\/jats:italic> determination of <jats:italic>\u03b2<\/jats:italic>\u2010lactam\u2010specific IgE antibodies was compared in three well\u2010defined groups of patients (<jats:italic>n<\/jats:italic>\u2003=\u200345): one with negative skin tests and a positive drug provocation test, another with positive skin tests, and a third control exposed population with good tolerance. Two techniques were used: the CAP\u2010FEIA system (Phadia<jats:sup>\u00ae<\/jats:sup>) commercially available and a homemade radioallergosorbent test (RAST).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The specificity of CAP\u2010FEIA ranged from 83.3% to 100% and sensitivity from 0% to 25% depending on initial clinical manifestations. The specificity of RAST was between 66.7% and 83.3% and sensitivity 42.9% and 75%. In the subgroup of patients with an anaphylactic shock and negative skin tests, the sensitivity and specificity of RAST were 75%. Positive and negative predictive values were 45.5% and 77.1% with CAP\u2010FEIA and 38.5% and 81.5% with RAST, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These results indicate that, although the specificity of <jats:italic>\u03b2<\/jats:italic>\u2010lactam\u2010specific IgE measurement is good, sensitivity is low. Immunoglobulin E measurement should be limited to patients with a clinical history of anaphylactic shock and negative skin tests in order to avoid a drug provocation test. More sensitive assays should be developed.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2006.01268.x","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T10:09:24Z","timestamp":1165399764000},"page":"47-52","source":"Crossref","is-referenced-by-count":159,"title":["Relevance of the determination of serum\u2010specific IgE antibodies in the diagnosis of immediate <i>\u03b2<\/i>\u2010lactam allergy"],"prefix":"10.1111","volume":"62","author":[{"given":"C.","family":"Fontaine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mayorga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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A comparison of the sensitivity and specificity of three Radio Allergo Sorbent Test (RAST) methods","volume":"11","author":"Garc\u00eda JJ","year":"1997","journal-title":"J Lab Clin Med"},{"key":"e_1_2_5_8_2","first-page":"240","article-title":"Diagnostic capabilities of penicillin\u2010based structures as tools in the in vitro diagnosis of penicillin allergy","volume":"2","author":"Daxun Z","year":"1992","journal-title":"J Invest Clin Immunol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00575.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.032"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02317.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01296.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2004.03.012"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.020"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2006.01268.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2006.01268.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:36:40Z","timestamp":1696883800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2006.01268.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,6]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1398-9995.2006.01268.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2006.01268.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,6]]}}}