{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:34:24Z","timestamp":1791200064771,"version":"4.2.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold>Skin testing with penicilloyl polylysine (PPL) and minor determinant mixture (MDM) represents the first\u2010line method for diagnosing<jats:italic>\u03b2<\/jats:italic>\u2010lactam hypersensitivity. However, in 2004, Allergopharma and Hollister\u2010Stier announced their decision to stop the production of penicillin reagents (Allergopen<jats:sup>\u00ae<\/jats:sup>and PrePen<jats:sup>\u00ae<\/jats:sup>, respectively) within 1\u2003year. Therefore, we decided to compare PPL and MDM from Allergopharma (Allergopen) with those from Diater (DAP<jats:sup>\u00ae<\/jats:sup>).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>We skin\u2010tested 195 subjects with both Allergopen and DAP reagents, as well as with other<jats:italic>\u03b2<\/jats:italic>\u2010lactams; 74 (group A) had had immediate reactions to<jats:italic>\u03b2<\/jats:italic>\u2010lactams and 74 (group B) nonimmediate reactions, while 47 (group C) underwent prophylactic tests.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>One hundred two patients (52.3%) had positive skin tests; 29 (14.9%) were positive to PPL and\/or MDM. Of the 102 skin\u2010test\u2010positive patients, 44 belonged to group A, 57 to B and 1 to C; the last was positive only to Allergopen PPL (PPL\u2010A) and tolerated the benzylpenicillin challenge. Minor determinant mixture reagents produced identical results in the 148 patients of groups A and B, 22 (14.9%) of which were positive. Both PPL reagents produced negative results in 139 of these 148 patients and positive ones in 5; one subject was positive to DAP PPL (PPL\u2010D) and negative to PPL\u2010A, while three patients were positive to PPL\u2010A and negative to PPL\u2010D; two of the latter tolerated benzylpenicillin challenges.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>Minor determinant mixture reagents produced identical results in all 195 patients. Results of skin testing with PPL reagents were concordant in 190 (97.4%) of them. Therefore, DAP reagents are a reliable alternative to Allergopen ones.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2006.01272.x","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T10:09:24Z","timestamp":1165399764000},"page":"53-58","source":"Crossref","is-referenced-by-count":45,"title":["A comparison of the performance of two penicillin reagent kits in the diagnosis of<i>\u03b2<\/i>\u2010lactam hypersensitivity"],"prefix":"10.1111","volume":"62","author":[{"given":"A.","family":"Romano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Viola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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