{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:03:29Z","timestamp":1789898609072,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:00:00Z","timestamp":1171929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> To describe the acute and late ocular manifestations and complications in toxic epidermal necrosis (TEN) and Stevens\u2013Johnson syndrome (SJS), and identify predictors for development of late complications.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Cases of TEN and SJS during a 9\u2010year period were included. Patients with ocular involvement were reviewed for acute ocular complications. Patients with a minimum 6\u2003months follow\u2010up were reviewed for late complications. Records were reviewed for their demographics, etiology, and severity of ocular involvement.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There were 117 patients with a mean age of 52.2\u2003\u00b1\u200318.6\u2003years. Eighty\u2010one of these (69%) had acute ocular involvement. This was mild in 40%, moderate in 25% and severe in 4%. Adverse drug reactions were the predominant cause. Patients with thrombocytopenia had more severe acute ocular involvement. Forty\u2010four patients had a minimum 6\u2003months of follow\u2010up and half developed late complications. Severe dry eyes and trichiatic lashes were the commonest late complications. Patients treated with topical antibiotic were more likely to have late complications, particularly dry eyes. There was no difference in the severity of acute eye involvement or late complications when SJS and TEN patients were compared. The severity of the acute ocular disease and abnormal laboratory tests were not found to be the significant risk factors of late complications.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Ocular involvement is common in SJS and TEN and can be severe and blinding. The severity of acute ocular complications does not predict late complications. The diagnosis of TEN does not imply a more severe ocular involvement or increased frequency of late ocular complications compared with SJS. Care should be taken even in mild cases. Appropriate intervention during acute ocular disease may prevent late complications.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2006.01295.x","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T10:36:32Z","timestamp":1171967792000},"page":"527-531","source":"Crossref","is-referenced-by-count":134,"title":["Ocular manifestations and complications of Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: an Asian series*"],"prefix":"10.1111","volume":"62","author":[{"given":"L. W.","family":"Yip","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Y.","family":"Thong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. B.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Handa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"Heng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61804-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1973.01000050378008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30811-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000183112.86181.9e"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(01)00246-6"},{"key":"e_1_2_6_9_2","first-page":"948","article-title":"Toxicity of natural tear substitutes in a fully defined culture model of human corneal epithelial cells","volume":"42","author":"Geerling G","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(95)30842-1"},{"key":"e_1_2_6_11_2","first-page":"1582","article-title":"The Fas\u2010Fas ligand system and other modulators of apoptosis in the cornea","volume":"37","author":"Wilson SE","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660330071012"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.120563"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.10.1191"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(88)33165-9"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-005-0607-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701653"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2006.01295.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2006.01295.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T21:10:24Z","timestamp":1696885824000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2006.01295.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,12]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1111\/j.1398-9995.2006.01295.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2006.01295.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,12]]}}}