{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:40:34Z","timestamp":1789756834858,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T00:00:00Z","timestamp":1173657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Eosinophil cationic protein (ECP) is a potent cytotoxic secretory protein with bactericidal and antiviral properties. ECP is released by activated eosinophils and regarded as a marker of eosinophilic inflammation. High levels of ECP have been reported in cases of active asthma and other allergic diseases. This study aimed to assess whether three single\u2010nucleotide polymorphisms (SNPs) in the <jats:italic>ECP<\/jats:italic> gene (<jats:italic>RNASE3<\/jats:italic>) on chromosome 14 q24\u2013q31 or their haplotypes are associated with asthma, allergy, or related phenotypes.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The three SNPs \u221238CA, +371CG and +499CG in <jats:italic>RNASE3<\/jats:italic> and their haplotypes were analyzed for associations with asthma, serum\u2010ECP (s\u2010ECP) levels, allergic sensitization (positive skin\u2010prick test to common allergens), bronchial hyperresponsiveness (BHR) assessed by methacholine inhalation, and serum\u2010IgE (s\u2010IgE) levels in 177 families from Norway and the Netherlands identified through siblings with asthma.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Transmission disequilibrium test (TDT) demonstrated significant associations between the A\u2010G\u2010G haplotype and asthma as well as the specific phenotypes allergic asthma (but not non\u2010allergic asthma), high s\u2010ECP, high s\u2010IgE and BHR, while the C\u2010G\u2010G haplotype was associated with reduced occurrence of these traits. In addition, the \u221238A allele was associated with high s\u2010ECP levels and allergic asthma.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The present study suggests that the A\u2010G\u2010G haplotype in the <jats:italic>RNASE3<\/jats:italic> gene influences the development of asthma, in particular, an allergic form of asthma. Furthermore, as the \u221238CA SNP lies in close vicinity of known intron\u2010regulatory sites, results of SNP analysis suggest that the detected association is possibly linked to a genetic transcriptional control of s\u2010ECP levels.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2007.01327.x","type":"journal-article","created":{"date-parts":[[2007,3,12]],"date-time":"2007-03-12T10:06:59Z","timestamp":1173694019000},"page":"429-436","source":"Crossref","is-referenced-by-count":35,"title":["Original article: Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s\u2010ECP levels and related phenotypes"],"prefix":"10.1111","volume":"62","author":[{"given":"M. C.","family":"Munthe\u2010Kaas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gerritsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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