{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:29:27Z","timestamp":1775510967611,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T00:00:00Z","timestamp":1179100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Extra\u2010fine particle formulations of hydrofluoroalkane\u2010134a beclometasone dipropionate (HFA\u2010BDP) exhibit clinical effects comparable with conventional particle formulations of chlorofluorocarbon beclometasone dipropionate (CFC\u2010BDP) at half the dose. There is little data comparing their effects on inflammation. We have evaluated the effects of HFA\u2010BDP and CFC\u2010BDP on pulmonary and systemic markers of asthmatic inflammation.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A double\u2010blind randomized crossover trial was undertaken comparing the anti\u2010inflammatory effects of HFA\u2010BDP (100 and 400\u2003<jats:italic>\u03bc<\/jats:italic>g\/day) and CFC\u2010BDP (200 and 800\u2003<jats:italic>\u03bc<\/jats:italic>g\/day). Treatment with montelukast was evaluated as add\u2010on to the higher dose of BDP.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Compared with baseline after withdrawal of usual asthma therapy, 100\u2003<jats:italic>\u03bc<\/jats:italic>g of HFA\u2010BDP significantly attenuated serum eosinophilic cationic protein levels (0.61\u2010fold change, 95% CI 0.49\u20130.77; a 39% reduction, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), but 200\u2003<jats:italic>\u03bc<\/jats:italic>g of CFC\u2010BDP did not (0.87\u2010fold change, 95% CI 0.63\u20131.23; <jats:italic>P<\/jats:italic>\u2003=\u20031). A dose of 800\u2003<jats:italic>\u03bc<\/jats:italic>g of CFC\u2010BDP and 400\u2003<jats:italic>\u03bc<\/jats:italic>g of HFA\u2010BDP led to reductions in exhaled nitric oxide (0.57\u2010fold change, 95% CI 0.44\u20130.73; a 43% reduction, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001 and 0.65\u2010fold change, 95% CI 0.47\u20130.91; a 35% reduction, <jats:italic>P<\/jats:italic>\u2003=\u20030.008, respectively); and peripheral eosinophils (\u221274\u2003cells\/<jats:italic>\u03bc<\/jats:italic>l, 95% CI \u2212146 to \u22122; <jats:italic>P<\/jats:italic>\u2003=\u20030.020 and \u221277\u2003cells\/<jats:italic>\u03bc<\/jats:italic>l, 95% CI \u2212140 to \u221214; <jats:italic>P<\/jats:italic>\u2003=\u20030.012, respectively). Montelukast further reduced exhaled nitric oxide (0.81\u2010fold change, 95% CI 0.66\u20130.98; <jats:italic>P<\/jats:italic>\u2003=\u20030.028) with 400\u2003<jats:italic>\u03bc<\/jats:italic>g HFA\u2010BDP and eosinophils (\u221244\u2003cells\/<jats:italic>\u03bc<\/jats:italic>l, 95% CI \u221280 to \u22128; <jats:italic>P<\/jats:italic>\u2003=\u20030.012) with 800\u2003<jats:italic>\u03bc<\/jats:italic>g CFC\u2010BDP, but not vice versa.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Chlorofluorocarbon beclometasone dipropionate and HFA\u2010BDP have differential effects on pulmonary and systemic inflammation, which dictate the additive effects of montelukast.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2007.01376.x","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T12:00:54Z","timestamp":1179144054000},"page":"661-667","source":"Crossref","is-referenced-by-count":16,"title":["Differential anti\u2010inflammatory effects of large and small particle size inhaled corticosteroids in asthma"],"prefix":"10.1111","volume":"62","author":[{"given":"D.","family":"Menzies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hopkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"McFarlane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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