{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:36:36Z","timestamp":1783355796995,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,8,4]],"date-time":"2007-08-04T00:00:00Z","timestamp":1186185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Despite constant exposure to micro\u2010organisms and other immunogenic environmental factors, relatively very few immunological responses are initiated in the nasal mucosa. Although several mechanisms could play a role in maintaining this immune suppressive milieu, none of them have been validated. Previous data from our group suggested that locally produced interleukin (IL)\u201010 could be involved in maintaining local homeostasis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> To investigate the role of epithelial IL\u201010 expression in the manifestation of allergic symptoms, we used immunohistochemistry to study the expression of IL\u201010 in the nasal epithelium of healthy individuals and house dust mite allergic patients. In the allergic patients, we determined potential correlations of epithelial expression with allergic symptoms, both at baseline and after allergen provocation.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> IL\u201010 is expressed in the basal and differentiated epithelial cells of both healthy individuals and allergic rhinitis patients. In the allergic individuals, there is a strong negative correlation at baseline between the epithelial expression level of IL\u201010 and rhinorrhoea and sneezing, but not between that expression level and nasal blockage or peak nasal inspiratory flow (PNIF). This correlation disappears with steroid treatment or after allergen provocation, although the expression at baseline seems to predict PNIF scores after provocation.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our data not only reveals IL\u201010 expression by human nasal epithelial cells, but also suggests that nasal epithelial IL\u201010 regulates allergic symptoms. Targeting the regulation mechanisms affecting IL\u201010 or targeting the regulation mechanism affected by IL\u201010 could constitute new options for the treatment of allergic disease.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2007.01419.x","type":"journal-article","created":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T03:05:52Z","timestamp":1186455952000},"page":"1014-1022","source":"Crossref","is-referenced-by-count":11,"title":["Nasal epithelial cells express IL\u201010 at levels that negatively correlate with clinical symptoms in patients with house dust mite allergy"],"prefix":"10.1111","volume":"62","author":[{"given":"B.","family":"Muller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J. J.","family":"De Groot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. J. 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