{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:12:10Z","timestamp":1792300330933,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T00:00:00Z","timestamp":1196812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> In contrast to the epidemiological and clinical association between allergic rhinitis and asthma, upper airway inflammation is less characterized in patients with nonatopic asthma and virtually unexplored in chronic obstructive pulmonary disease (COPD). Here, sinonasal pathology is studied in patients with allergic asthma, nonallergic asthma and COPD.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Ninety patients with stable bronchial disease were included in the study, of which 35 were diagnosed with allergic asthma, 24 with nonallergic asthma and 31 with COPD. Concurrently, 61 control subjects without pulmonary disease were included and matched for age and smoking habits respectively with the asthma and the COPD group. Sinonasal symptoms were evaluated on a visual analogue scale and rhinosinusitis\u2010related impairment of quality of life was assessed with the sino\u2010nasal outcome test\u201022 (SNOT\u201022) questionnaire. Nasal mucosal abnormalities were quantified with nasal endoscopy and nasal secretions collected for measuring inflammatory mediators.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Allergic asthmatics, nonallergic asthmatics and COPD patients reported more nasal symptoms than their respective control subjects, had a higher SNOT\u201022 score and presented more mucosal abnormalities in the nose. Nasal secretions of both allergic and nonallergic asthmatics contained higher levels of eotaxin, G\u2010CSF, IFN\u2010\u03b3 and MCP\u20101 than controls. Allergic asthmatics had higher nasal IP\u201010 levels as well. COPD\u2010patients had higher nasal levels of eotaxin, G\u2010CSF and IFN\u2010\u03b3 than controls.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Patients with allergic and nonallergic asthma and COPD show increased nasal symptoms and more nasal inflammation. Hence, our data confirm the \u2018united airways\u2019 concept to be beyond the scope of allergic asthma.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2007.01545.x","type":"journal-article","created":{"date-parts":[[2008,2,4]],"date-time":"2008-02-04T10:02:27Z","timestamp":1202119347000},"page":"261-267","source":"Crossref","is-referenced-by-count":125,"title":["Original article: Sinonasal pathology in nonallergic asthma and COPD: \u2018united airway disease\u2019 beyond the scope of allergy"],"prefix":"10.1111","volume":"63","author":[{"given":"G.","family":"Hens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M.","family":"Vanaudenaerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M. A.","family":"Bullens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Piessens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Decramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Ceuppens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W.","family":"Hellings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118891"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.110151"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.121701"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70370-2"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9912030"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17405960"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(03)00114-8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.01.010"},{"key":"e_1_2_6_10_2","first-page":"209","article-title":"Rhinitis in the elderly","volume":"19","author":"Sahin\u2010Yilmaz AA","year":"2007","journal-title":"Clin Allergy Immunol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.23504.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(77)90171-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01970.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61266-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.4.1219"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.006650"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.121022"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.9912001"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.1.109"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.052399"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02968.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.5.8912771"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb04934.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/156801005774912806"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.4.2"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2006.05.002"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.26.6.4757"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2007.01545.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2007.01545.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:50:59Z","timestamp":1696909859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2007.01545.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,4]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1111\/j.1398-9995.2007.01545.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2007.01545.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,4]]}}}