{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:40:51Z","timestamp":1761986451071},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T00:00:00Z","timestamp":1195430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Lupin has now been introduced into food production in the UK. There is a concern that, on account of cross\u2010reactivity, peanut\u2010allergic children are at high risk for lupin allergy.<\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> To investigate the prevalence of lupin sensitization and allergy in children with peanut allergy compared with atopic controls.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Children (&lt;18\u2003years) were recruited. Peanut\u2010allergic subjects either had a convincing history of peanut allergy with diagnostic peanut skin prick test (SPT) or specific\u2010immunoglobulin E (IgE) results or a positive food challenge. Control subjects were atopic but not peanut\u2010allergic. All subjects had SPT to peanut and lupin. Sensitized subjects were offered a randomized, double\u2010blind, placebo\u2010controlled lupin challenge. Lupin allergy was defined as objective immediate hypersensitivity reaction at food challenge.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Forty\u2010seven peanut\u2010allergic children and 46 atopic controls were recruited. Sixteen peanut\u2010allergic children were sensitized to lupin [34%, 95% confidence interval (CI): 21\u201349%]. Nine were challenged to lupin. Two reacted (itchy mouth and urticaria; itchy mouth and 20% drop in peak expiratory flow rate) giving a minimum prevalence of lupin allergy in peanut\u2010allergic children of 4.0% (95% CI: 1\u201315%). Atopic controls were significantly (<jats:italic>P<\/jats:italic>\u2003=\u20030.001) less likely to be sensitized to lupin (4%, 95% CI: 1\u201315%) and had smaller wheals and serum\u2010specific IgE results. None of the atopic controls reacted on lupin challenge, giving a rate of allergy in the atopic controls of 0% (95% CI: 0\u20138%).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> A small but significant number of children with peanut allergy are allergic to lupin. Sensitization to lupin is much rarer in nonpeanut\u2010allergic atopic subjects.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2007.01568.x","type":"journal-article","created":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T04:04:47Z","timestamp":1195531487000},"page":"370-373","source":"Crossref","is-referenced-by-count":67,"title":["Short communication: Lupin allergy in peanut\u2010allergic children and teenagers"],"prefix":"10.1111","volume":"63","author":[{"given":"J.","family":"Shaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Grimshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hourihane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09831-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/ai.1994.v94.a54942"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70303-9"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70203-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62838-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116860"},{"key":"e_1_2_6_8_2","first-page":"213","article-title":"Allergenicity of lupine flour","volume":"34","author":"Leduc V","year":"2002","journal-title":"Allerg Immunol"},{"issue":"140","key":"e_1_2_6_9_2","first-page":"S11","article-title":"Lupine anaphylaxis: a new food allergy in children","volume":"134","author":"Wassenberg J","year":"2004","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00299.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61036-7"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000094181"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00305.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114708"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00928.x"},{"key":"e_1_2_6_16_2","volume-title":"Annex IIIa of Directive 2000\/13\/EC of the European Parliament and of the Council listing the ingredients which must under all circumstances appear on the labelling of foodstuffs","author":"Commission Directive 2006\/142\/EC of 22 December 2006 amending"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2007.01568.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2007.01568.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T03:51:50Z","timestamp":1696909910000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2007.01568.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,4]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1111\/j.1398-9995.2007.01568.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2007.01568.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,4]]}}}