{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:06:04Z","timestamp":1793048764247,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,4]],"date-time":"2008-01-04T00:00:00Z","timestamp":1199404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Excessive mast cell mediator release may lead to anaphylaxis in patients with mastocytosis. However, the incidence, clinical features and trigger factors have not yet been analyzed.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> To identify risk factors for anaphylaxis in mastocytosis, we determined cumulative incidence, severity, clinical characteristics, and trigger factors for anaphylaxis in 120 consecutive patients (53 male; 67 female, median age and range 24\u2003years, 1\u2003month to 73\u2003years), and correlated these with disease severity of mastocytosis, skin involvement, basal total serum tryptase, and diaminooxidase concentrations.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The cumulative incidence of anaphylaxis in patients with mastocytosis was higher in adults (49%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) compared with that in children (9%). Only children with extensive skin involvement had experienced anaphylaxis. In adults, anaphylaxis was correlated to the absence of urticaria pigmentosa lesions (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.03). Reactions occurred more frequently in adults with systemic (56%) when compared with cutaneous mastocytosis (13%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.02). In adults, 48% of reactions were severe, and 38% resulted in unconsciousness. Major perceived trigger factors for adults were hymenoptera stings (19%), foods (16%), and medication (9%); however, in 26% of reactions, only a combination of different triggers preceded anaphylaxis. Trigger factors remained unidentified in 67% of reactions in children compared with 13% in adults. Patients with anaphylaxis had higher basal tryptase values (60.2\u2003\u00b1\u200355\u2003ng\/ml, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) in comparison with those without (21.2\u2003\u00b1\u200333\u2003ng\/ml), but not diaminooxidase levels.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Adult patients and children with extensive skin disease with mastocytosis have an increased risk to develop severe anaphylaxis; thus, an emergency set of medication including epinephrine is recommended.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2007.01569.x","type":"journal-article","created":{"date-parts":[[2010,8,17]],"date-time":"2010-08-17T12:31:43Z","timestamp":1282048303000},"page":"226-232","source":"Crossref","is-referenced-by-count":446,"title":["Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 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