{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:29:01Z","timestamp":1774124941989,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T00:00:00Z","timestamp":1204502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Ozone (O<jats:sub>3<\/jats:sub>) exposure evokes asthma exacerbations by mechanisms that are poorly understood. We used a murine model to characterize the effects of O<jats:sub>3<\/jats:sub> on allergic airway inflammation and hyperresponsiveness and to identify factors that might contribute to the O<jats:sub>3<\/jats:sub>\u2010induced exacerbation of asthma.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> BALB\/c mice were sensitized and challenged with <jats:italic>Aspergillus fumigatus<\/jats:italic> (<jats:italic>Af<\/jats:italic>). A group of sensitized and challenged mice was exposed to 3.0\u2003ppm of O<jats:sub>3<\/jats:sub> for 2\u2003h and studied 12\u2003h later (96\u2003h after <jats:italic>Af<\/jats:italic> challenge). Naive mice and mice exposed to O<jats:sub>3<\/jats:sub> alone were used as controls. Bronchoalveolar lavage (BAL) cellular and cytokine content, lung function [enhanced pause (P<jats:sub>enh<\/jats:sub>)], isometric force generation by tracheal rings and gene and protein expression of Fas and FasL were assessed. Apoptosis of eosinophils was quantified by FACS.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In sensitized mice allergen challenge induced a significant increase of P<jats:sub>enh<\/jats:sub> and contractile force in tracheal rings that peaked 24\u2003h after challenge and resolved by 96\u2003h. O<jats:sub>3<\/jats:sub> inhalation induced an exacerbation of airway hyperresponsiveness accompanied by recurrence of neutrophils and enhancement of eosinophils 96\u2003h after allergen challenge. The combination of allergen and O<jats:sub>3<\/jats:sub> exposure inhibited Fas and FasL gene and protein expression and eosinophil apoptosis and increased interleukin\u20105 (IL\u20105), granulocyte\u2010macrophage\u2010colony stimulating factor (GM\u2010CSF) and G\u2010CSF protein levels.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> O<jats:sub>3<\/jats:sub> affects airway responsiveness of allergen\u2010primed airways indirectly by increasing viability of eosinophils and eosinophil\u2010mediated pathological changes.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2007.01587.x","type":"journal-article","created":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T00:09:40Z","timestamp":1204589380000},"page":"438-446","source":"Crossref","is-referenced-by-count":58,"title":["Ozone inhalation induces exacerbation of eosinophilic airway inflammation and hyperresponsiveness in allergen\u2010sensitized mice"],"prefix":"10.1111","volume":"63","author":[{"given":"S.","family":"Kierstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Krytska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Amrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"R. 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