{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:31:04Z","timestamp":1772173864565,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,2,25]],"date-time":"2008-02-25T00:00:00Z","timestamp":1203897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>Mycobacterium bovis<\/jats:italic> Bacillus Calmette\u2010Gu\u00e9rin (BCG) vaccination has been shown to inhibit allergic airway inflammation in animal models, associated with the regulation of allergen\u2010specific T\u2010cell immunity. However, little is known about whether neonatal BCG treatment could inhibit allergic inflammation by regulating allergen\u2010specific T\u2010cell response in aged mice. This study was aimed to investigate the impact of neonatal BCG treatment on allergic asthma and possible mechanism(s) underlying the action of BCG in different ages of mice.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> C57BL\/6 neonates were vaccinated with BCG on days 1, 7 and 14, sensitized with ovalbumin (OVA) at 5 and 7\u2003weeks of age, and then challenged with allergen at 9 or 45\u2003weeks of age for early\u2010 or late\u2010challenged asthma. Their airway inflammation and allergen\u2010specific T\u2010cell responses were characterized.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Following early\u2010challenge, BCG vaccination inhibited airway hyper\u2010responsiveness (AHR), infiltration of eosinophils and mucous overproduction (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05), and shifted OVA\u2010specific predominant Th2\u2010 to Th1\u2010type cytokine responses in both the bronchoalveolar lavage fluid and the splenocyte supernatants (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). In late\u2010challenged mice, neonatal BCG treatment attenuated AHR and eosinophilia (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05), but failed to modulate allergen\u2010specific cytokine responses.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our data suggest that neonatal BCG vaccination has a long\u2010term effect on inhibiting AHR and eosinophilia, which is associated with the modulation of Th1\/Th2 cytokine production in early\u2010, but not in late\u2010challenged mice. Thus, different mechanisms may mediate the long\u2010term protective effect of BCG neonatal vaccination differently in younger adult and aged mice.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2008.01637.x","type":"journal-article","created":{"date-parts":[[2008,2,25]],"date-time":"2008-02-25T09:32:08Z","timestamp":1203931928000},"page":"555-563","source":"Crossref","is-referenced-by-count":33,"title":["Neonatal vaccination with Bacillus Calmette\u2010Gu\u00e9rin elicits long\u2010term protection in mouse\u2010allergic 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