{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:55:16Z","timestamp":1778813716367,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T00:00:00Z","timestamp":1217980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The daily dose of aspirin in desensitization in aspirin\u2010sensitive asthmatics with nasal polyps is still a matter of debate.<\/jats:p><jats:p><jats:bold>Aims of the study:\u2002<\/jats:bold> To compare two doses of aspirin during the first year of desensitization and to evaluate long\u2010term effects on nasal\/pulmonary symptoms.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Patients with positive aspirin provocation test were treated with either 100 or 300\u2003mg aspirin daily.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In all patients taking 100\u2003mg aspirin (<jats:italic>n<\/jats:italic>\u2003=\u20037) recurrent nasal polyps were observed. No patient experienced reduction of asthma medication or improvement of pulmonary function. In the 300\u2003mg group no recurrent nasal polyps were seen. Asthma medication could be reduced in three patients, pulmonary function was improved in five patients. Thirty\u2010nine consecutively desensitized patients, taking 300\u2003mg aspirin, showed significant improvement of olfaction and polyp\u2010free nasal passages during the first year of therapy. After a median follow\u2010up of 27\u2003months no sinus revision surgery was necessary.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Aspirin desensitization followed by 300\u2003mg aspirin daily is efficacious and results in polyp\u2010free nasal airways, improvement of sense of smell, and reduction of the need for sinus revision surgery for recurrent nasal polyps. Aspirin in a dose of 100\u2003mg daily is not sufficient to effectively reduce nasal and bronchial or pulmonary symptoms and to prevent recurrent nasal polyps by at least the first 12\u2003months of treatment.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2008.01658.x","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T08:32:10Z","timestamp":1218011530000},"page":"1228-1234","source":"Crossref","is-referenced-by-count":126,"title":["Long\u2010term treatment with aspirin desensitization: a prospective clinical trial comparing 100 and 300\u2003mg aspirin daily"],"prefix":"10.1111","volume":"63","author":[{"given":"A.","family":"Rozsasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Polzehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Deutschle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Wiesmiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Riechelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Keck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1487"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003000-00017"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.03.038"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62468-4"},{"key":"e_1_2_6_6_2","first-page":"79","article-title":"Recurrence rates in endonasal surgery for polyposis","volume":"58","author":"Albu S","year":"2004","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_6_7_2","first-page":"235","article-title":"Phenomenology, pathogenesis, diagnosis and treatment of aspirin\u2010sensitive rhinosinusitis","volume":"49","author":"Schapowal AG","year":"1995","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(80)90143-8"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(84)90361-0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70123-9"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00025.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01409.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.7"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.011"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(83)90437-2"},{"key":"e_1_2_6_16_2","first-page":"219","article-title":"Clinical efficacy of aspirin in \u201cdesensitized\u201d aspirin\u2010sensitive asthmatics","volume":"69","author":"Kowalski ML","year":"1986","journal-title":"Eur J Respir Dis"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90222-P"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.5414\/ALP29322"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.3.316"},{"key":"e_1_2_6_20_2","first-page":"588","article-title":"Intranasal treatment with lysine acetylsalicylate in patients with nasal polyposis","volume":"67","author":"Patriarca G","year":"1991","journal-title":"Ann Allergy"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000166702.38850.1B"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.ats11-99"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489709113422"},{"key":"e_1_2_6_24_2","first-page":"169","article-title":"Consensus report on acoustic rhinometry and rhinomanometry","volume":"43","author":"Clement PAR","year":"2005","journal-title":"Rhinology"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00668.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d08.x"},{"key":"e_1_2_6_28_2","volume-title":"Global Initiative for Asthma. 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