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In asthma, chronic Th\u20102 driven eosinophilic inflammation of the airways is one of the central abnormalities. To date, elucidating the role of the different pro\u2010inflammatory mediators involved in orchestrating the inflammatory processes in asthma has been the subject of intense research in both humans and animal models. However, the counter\u2010regulatory mechanisms that co\u2010determine the outcome in the contest of resolution <jats:italic>vs<\/jats:italic> persistence of the eosinophilic airway inflammation remain poorly understood. These are currently being investigated in animal models of chronic asthma. Elucidating these mechanisms is of relevance, since it can give rise to a new therapeutic approach in the treatment of chronic airway inflammation in asthmatics. This novel concept of treatment involves the stimulation of <jats:italic>endogenous<\/jats:italic> anti\u2010inflammatory pathways, rather than solely antagonising the various pro\u2010inflammatory mediators. Here, we review and discuss the current knowledge about these <jats:italic>endogenous<\/jats:italic> anti\u2010inflammatory mediators in clinical and experimental asthma.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2008.01772.x","type":"journal-article","created":{"date-parts":[[2008,7,8]],"date-time":"2008-07-08T19:49:35Z","timestamp":1215546575000},"page":"1095-1109","source":"Crossref","is-referenced-by-count":25,"title":["Chronic inflammation in asthma: a contest of persistence <i>vs<\/i> resolution"],"prefix":"10.1111","volume":"63","author":[{"given":"C. L.","family":"Van Hove","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. F.","family":"Joos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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