{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:32:50Z","timestamp":1791246770318,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T00:00:00Z","timestamp":1288310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:bold>To cite this article:<\/jats:bold> Blumchen K, Bayer P, Buck D, Michael T, Cremer R, Fricke C, Henne T, Peters H, Hofmann U, Keil T, Schlaud M, Wahn U, Niggemann B. Effects of latex avoidance on latex sensitization, atopy and allergic diseases in patients with spina bifida. <jats:italic>Allergy<\/jats:italic> 2010; <jats:bold>65<\/jats:bold>: 1585\u20131593.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Ten years ago, avoidance measures such as the performance of latex\u2010free operations were implemented in children with spina bifida. Since then, latex sensitization and latex allergy have decreased in this high\u2010risk group.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To study the effect of primary latex\u2010free prophylaxis on the prevalence of allergic diseases and atopy as a marker for sensitization spreading in children with spina bifida.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> One hundred and twenty children with spina bifida born after the introduction of latex\u2010free prophylaxis and operated on under latex\u2010free conditions (\u2018current group\u2019) were examined for latex sensitization, latex allergy, sensitization to aero\u2010 and food allergens and allergic diseases. Results were compared to a \u2018historic\u2019 (not latex\u2010free operated) group of children with spina bifida and comparable age (<jats:italic>n<\/jats:italic>\u2003=\u200387) and to a recent sample of children from the general population (<jats:italic>n<\/jats:italic>\u2003=\u200312\u2003403).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In comparison with the \u2018historic group\u2019, latex sensitization (55%<jats:italic>vs<\/jats:italic> 5%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and latex allergy (37%<jats:italic>vs<\/jats:italic> 0.8%, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) were significantly reduced in the \u2018current group\u2019. Furthermore, a significant reduction could be demonstrated for sensitization to aeroallergens (41.4%<jats:italic>vs<\/jats:italic> 20.8%, <jats:italic>P<\/jats:italic>\u2003=\u20030.001) and for allergic diseases (35%<jats:italic>vs<\/jats:italic> 15%, <jats:italic>P<\/jats:italic>\u2003=\u20030.001). The prevalence for atopy, sensitization to aero\u2010\/foodallergens and for allergic diseases in children of the \u2018current group\u2019 was similar to those in children of the weighted population sample.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Latex avoidance in children with spina bifida prevents latex sensitization and latex allergy. Additionally, it also seems to prevent sensitization to other allergens and allergic diseases which might be explained by the prevention of sensitization spreading.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1398-9995.2010.02447.x","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T15:02:01Z","timestamp":1279897321000},"page":"1585-1593","source":"Crossref","is-referenced-by-count":30,"title":["Effects of latex avoidance on latex sensitization, atopy and allergic diseases in patients with spina 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