{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:45:25Z","timestamp":1793915125098,"version":"4.8.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T00:00:00Z","timestamp":1314921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>To cite this article:<\/jats:bold>\n                      Videler WJ, Badia L, Harvey RJ, Gane S, Georgalas C, van der Meulen FW, Menger DJ, Lehtonen MT, Toppila\u2010Salmi SK, Vento SI, Hyt\u00f6nen M, Hellings PW, Kalogjera L, Lund VJ, Scadding G, Mullol J, Fokkens WJ. Lack of Efficacy of long\u2010term, low\u2010dose azithromycin in chronic rhinosinusitis: a randomized controlled trial.\n                      <jats:italic>Allergy<\/jats:italic>\n                      2011;\n                      <jats:bold>66<\/jats:bold>\n                      : 1457\u20131468.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Background:\u2002<\/jats:bold>\n                      In persistent chronic rhinosinusitis (CRS), conventional treatment is often insufficient. Long\u2010term, low\u2010dose administration of macrolides has been suggested as a treatment option. The MACS (Macrolides in chronic rhinosinusitis) study is a randomized placebo\u2010controlled trial evaluating the efficacy of azithromycin (AZM) in CRS.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Methods:\u2002<\/jats:bold>\n                      We describe a group of patients with recalcitrant CRS with and without nasal polyps unresponsive to optimal medical and (in 92% also) surgical treatment. Patients were treated with AZM or placebo. AZM was given for 3\u2003days at 500\u2003mg during the first week, followed by 500\u2003mg per week for the next 11\u2003weeks. Patients were monitored until 3\u2003months post\u2010therapy. The assessments included Sino\u2010Nasal Outcome Test\u201022 (SNOT\u201022), a Patient Response Rating Scale, Visual Analogue Scale (VAS), Short Form\u201036 (SF\u201036), rigid nasal endoscopy, peak nasal inspiratory flow (PNIF), Sniffin\u2019 Sticks smell tests and endoscopically guided middle meatus cultures.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Results:\u2002<\/jats:bold>\n                      Sixty patients with a median age of 49\u2003years were included. Fifty per cent had asthma and 58% had undergone revision sinus surgery. In the SNOT\u201022, Patient Response Rating Scale, VAS scores and SF\u201036, no significant difference between the AZM and the placebo groups was demonstrated. Nasal endoscopic findings, PNIF results, smell tests and microbiology showed no relevant significant differences between the groups either.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Conclusion:\u2002<\/jats:bold>\n                      At the investigated dose of AZM over 3\u2003months, no significant benefit was found over placebo. Possible reasons could be disease severity in the investigated group, under\u2010dosage of AZM and under\u2010powering of the study. Therefore, more research is urgently required.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1398-9995.2011.02693.x","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T06:27:25Z","timestamp":1314944845000},"page":"1457-1468","source":"Crossref","is-referenced-by-count":158,"title":["Lack of efficacy of long\u2010term, low\u2010dose azithromycin in chronic rhinosinusitis: a randomized controlled trial"],"prefix":"10.1111","volume":"66","author":[{"given":"W. J.","family":"Videler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Badia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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