{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:57:49Z","timestamp":1794002269295,"version":"4.8.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T00:00:00Z","timestamp":1320364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>To cite this article:<\/jats:bold>\n                      Jarvis D, Newson R, Lotvall J, Hastan D, Tomassen P, Keil T, Gjomarkaj M, Forsberg B, Gunnbjornsdottir M, Minov J, Brozek G, Dahlen SE, Toskala E, Kowalski ML, Olze H, Howarth P, Kr\u00e4mer U, Baelum J, Loureiro C, Kasper L, Bousquet PJ, Bousquet J, Bachert C, Fokkens W, Burney P. Asthma in adults and its association with chronic rhinosinusitis: The GA\n                      <jats:sup>2<\/jats:sup>\n                      LEN survey in Europe.\n                      <jats:italic>Allergy<\/jats:italic>\n                      2012;\n                      <jats:bold>67<\/jats:bold>\n                      : 91\u201398.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Background:\u2002<\/jats:bold>\n                      The prevalence of asthma and its association with chronic rhinosinusitis (CRS) have not been widely studied in population\u2010based epidemiological surveys.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Methods:\u2002<\/jats:bold>\n                      The Global Allergy and Asthma Network of Excellence (GA\n                      <jats:sup>2<\/jats:sup>\n                      LEN) conducted a postal questionnaire in representative samples of adults living in Europe to assess the presence of asthma and CRS defined by the European Position Paper on Rhinosinusitis and Nasal Polyps. The prevalence of self\u2010reported current asthma by age group was determined. The association of asthma with CRS in each participating centre was assessed using logistic regression analyses, controlling for age, sex and smoking, and the effect estimates were combined using standard methods of meta\u2010analysis.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Results:\u2002<\/jats:bold>\n                      Over 52\u2003000 adults aged 18\u201375\u2003years and living in 19 centres in 12 countries took part. In most centres, and overall, the reported prevalence of asthma was lower in older adults (adjusted OR for 65\u201374\u2003years compared with 15\u201324\u2003years: 0.72; 95% CI: 0.63\u20130.81). In all centres, there was a strong association of asthma with CRS (adjusted OR: 3.47; 95% CI: 3.20\u20133.76) at all ages. The association with asthma was stronger in those reporting both CRS and allergic rhinitis (adjusted OR: 11.85; 95% CI: 10.57\u201313.17). CRS in the absence of nasal allergies was positively associated with late\u2010onset asthma.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Conclusion:\u2002<\/jats:bold>\n                      Geographical variation in the prevalence of self\u2010reported asthma was observed across Europe, but overall, self\u2010reported asthma was more common in young adults, women and smokers. In all age groups, men and women, and irrespective of smoking behaviour, asthma was also associated with CRS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1398-9995.2011.02709.x","type":"journal-article","created":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T07:22:49Z","timestamp":1320391369000},"page":"91-98","source":"Crossref","is-referenced-by-count":434,"title":["Asthma in adults and its association with chronic rhinosinusitis: The GA\n                    <sup>2<\/sup>\n                    LEN survey in Europe"],"prefix":"10.1111","volume":"67","author":[{"given":"D.","family":"Jarvis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Newson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lotvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Hastan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tomassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Keil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gjomarkaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gunnbjornsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Minov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Brozek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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