{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:37Z","timestamp":1791274417658,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T00:00:00Z","timestamp":1316390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:bold>To cite this article:<\/jats:bold> Dunstan JA, West C, McCarthy S, Metcalfe J, Meldrum S, Oddy WH, Tulic MK, D\u2019Vaz N, Prescott SL. The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood. <jats:italic>Allergy<\/jats:italic> 2012; <jats:bold>67<\/jats:bold>: 50\u201357.<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Dietary changes may epigenetically modify fetal gene expression during critical periods of development to potentially influence disease susceptibility. This study examined whether maternal and\/or fetal folate status in pregnancy is associated with infant allergic outcomes.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Pregnant women (<jats:italic>n<\/jats:italic>\u2003=\u2003628) were recruited in the last trimester of pregnancy. Folate status determined by both food frequency questionnaires and folate levels in maternal and cord blood serum was examined in relation to infant allergic outcomes at 1\u2003year of age (<jats:italic>n<\/jats:italic>\u2003=\u2003484).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Infants who developed allergic disease (namely eczema) did not show any differences in cord blood or maternal folate levels compared with children without disease. Although maternal folate intake from foods was also not different, folate derived from supplements was higher (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.017) in children with subsequent eczema. Furthermore, infants exposed to &gt;500\u2003\u03bcg folic acid\/day as a supplement <jats:italic>in utero<\/jats:italic> were more likely to develop eczema than those taking &lt;200\u2003\u03bcg\/day (OR [odds ratio]\u2003=\u20031.85; 95% CI 1.14\u20133.02; <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.013), remaining significant after adjustment for maternal allergy and other confounders. There was a nonlinear relationship between cord blood folate and sensitization, with folate levels &lt;50\u2003nmol\/l (OR\u2003=\u20033.02; 95% CI 1.16\u20137.87; <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.024) and &gt;75\u2003nmol\/l (OR\u2003=\u20033.59; 95% CI 1.40\u20139.20; <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.008) associated with greater sensitization risk than levels between 50 and 75\u2003nmol\/l.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Fetal levels between 50 and 75\u2003nmol\/l appeared optimal for minimizing sensitization. While folate taken as a supplement in higher doses during the third trimester was associated with eczema, there was no effect on other allergic outcomes including sensitization. Further studies are needed to determine the significance of this.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1398-9995.2011.02714.x","type":"journal-article","created":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T09:29:23Z","timestamp":1316424563000},"page":"50-57","source":"Crossref","is-referenced-by-count":74,"title":["The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood"],"prefix":"10.1111","volume":"67","author":[{"given":"J. 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K.","family":"Tulic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"D\u2019Vaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,19]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.001206"},{"key":"e_1_2_10_3_2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/MOP.0b013e32833d96ef","article-title":"Role of diet in the development of immune tolerance in the context of allergic disease","volume":"22","author":"West CE","year":"2010","journal-title":"Curr Opin Pediatr"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20536"},{"key":"e_1_2_10_5_2","first-page":"3462","article-title":"In utero supplementation with methyl donors enhances allergic airway disease in mice","volume":"118","author":"Hollingsworth JW","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.142448"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp315"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.04.023"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.004"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2011.05.019"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.5.1392"},{"key":"e_1_2_10_12_2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/jn\/138.3.551","article-title":"Lowering plasma homocysteine concentrations of older men and women with folate, vitamin B\u201012, and vitamin B\u20106 does not affect the proportion of (n\u20103) long chain polyunsaturated fatty acids in plasma phosphatidylcholine","volume":"138","author":"Crowe FL","year":"2008","journal-title":"J Nutr"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(00)00027-4"},{"key":"e_1_2_10_14_2","volume-title":"Dietary reference intakes: thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline","author":"Institute of Medicine FaNB","year":"1998"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181c2bde8"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1690"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29361"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2011.02714.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2011.02714.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:36:07Z","timestamp":1698755767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2011.02714.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,19]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1398-9995.2011.02714.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2011.02714.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,19]]}}}