{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:25:46Z","timestamp":1794432346357,"version":"4.9.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T00:00:00Z","timestamp":1316563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>To cite this article:<\/jats:bold>\n                      Yamaki K, Yoshino S. Tyrosine kinase inhibitor sunitinib relieves systemic and oral antigen\u2010induced anaphylaxes in mice.\n                      <jats:italic>Allergy<\/jats:italic>\n                      2012;\n                      <jats:bold>67<\/jats:bold>\n                      : 114\u2013122.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Background:\u2002<\/jats:bold>\n                      Systemic and oral antigen\u2010induced anaphylaxes are mediated by immunoglobulin (Ig) E and mast cells, but there is no satisfactory treatment for the life\u2010threatening allergic reaction. We investigated the potential of the multitargeted receptor tyrosine kinase inhibitor sunitinib to relieve anaphylactic reactions in food allergy and systemic anaphylaxis.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Methods:\u2002<\/jats:bold>\n                      Efficacy of oral sunitinib on oral and parenteral antigen\u2010induced anaphylaxes in Balb\/c mice was evaluated. IgE\u2010dependent degranulation and growth of rat basophilic leukemia RBL2H3 and bone marrow\u2010derived mast cells (BMMCs) in response to sunitinib were investigated.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Results:\u2002<\/jats:bold>\n                      Daily administration of sunitinib throughout antigen challenges prevented oral antigen\u2010induced anaphylaxis including diarrhea, anaphylactic symptoms, and hypothermia. The mouse mast cell protease (MMCP)\u20101 concentration in serum and mast cell number in intestinal tissue after challenge were also decreased by the treatment. Spleen cells from sunitinib\u2010treated mice contained smaller numbers of antigen\u2010specific IgG\u2010producing cells and secreted lower amounts of both Th1 and Th2 cytokines than those of the control mice, whereas the levels of antigen\u2010specific antibodies in serum were not decreased. The reactions and MMCP\u20101 release in oral antigen\u2010induced anaphylaxis and passive systemic anaphylaxis were attenuated even by a single predose of sunitinib. Degranulation and growth of RBL2H3 cells and BMMCs were greatly reduced by sunitinib.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Conclusion:\u2002<\/jats:bold>\n                      These results suggested that sunitinib relieves systemic and oral antigen\u2010induced anaphylaxes by the prevention of mast cell activation and hyperplasia in intestinal tissue directly and indirectly through an immunosuppressive effect. Sunitinib and its related kinase inhibitors might be potential drugs for the treatment of food allergy and systemic anaphylaxis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1398-9995.2011.02717.x","type":"journal-article","created":{"date-parts":[[2011,9,21]],"date-time":"2011-09-21T05:10:54Z","timestamp":1316581854000},"page":"114-122","source":"Crossref","is-referenced-by-count":34,"title":["Tyrosine kinase inhibitor sunitinib relieves systemic and oral antigen\u2010induced anaphylaxes in mice"],"prefix":"10.1111","volume":"67","author":[{"given":"K.","family":"Yamaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,21]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-006-0022-8"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115047"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19785"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2001.790107.x"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.123238"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706253162603"},{"key":"e_1_2_10_8_2","first-page":"471","article-title":"SU11248 inhibits KIT and platelet\u2010derived growth factor receptor beta in preclinical models of human small cell lung cancer","volume":"2","author":"Abrams TJ","year":"2003","journal-title":"Mol Cancer Ther"},{"key":"e_1_2_10_9_2","first-page":"327","article-title":"In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet\u2010derived growth factor receptors: determination of a pharmacokinetic\/pharmacodynamic relationship","volume":"9","author":"Mendel DB","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.15.5.553"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.9.2237.2237"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000236870"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-009-9254-z"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2005.01662.x"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.001"},{"key":"e_1_2_10_16_2","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.4049\/jimmunol.154.10.5391","article-title":"Activation of the mitogen\u2010activated protein kinase\/cytosolic phospholipase A2 pathway in a rat mast cell line. 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