{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:57:52Z","timestamp":1789372672890,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T00:00:00Z","timestamp":1324512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,3]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n \n Regulatory\n T<\/jats:styled-content>\n cells (\n T<\/jats:styled-content>\n regs) with stable\n \n FOXP3<\/jats:italic>\n <\/jats:styled-content>\n expression are characterized by a specific demethylated region in the\n \n FOXP3<\/jats:italic>\n <\/jats:styled-content>\n gene (\n T<\/jats:styled-content>\n reg\u2010specific demethylated region,\n TSDR<\/jats:styled-content>\n ). The aim of this study was to analyse the influence of prenatal factors on cord blood\n T<\/jats:styled-content>\n reg numbers, as detected by changes in the\n TSDR<\/jats:styled-content>\n demethylation, and the subsequent risk for allergic diseases.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Analyses were performed within the\n LINA<\/jats:styled-content>\n study in blood samples from pregnant women (34th gestational week) and in cord blood (\n n<\/jats:italic>\n \u00a0=\u00a0346 mother\u2013child pairs).\n T<\/jats:styled-content>\n reg numbers were detected via\n DNA<\/jats:styled-content>\n demethylation in the\n \n FOXP3<\/jats:italic>\n TSDR\n <\/jats:styled-content>\n . At age 1, total and specific\n I<\/jats:styled-content>\n g\n E<\/jats:styled-content>\n was measured in children's blood. In addition, maternal cytokine production (\n T<\/jats:styled-content>\n h1\/\n T<\/jats:styled-content>\n h2\/\n T<\/jats:styled-content>\n h17) was analysed. Exposure and disease outcomes were assessed by questionnaires.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Boys had lower\n T<\/jats:styled-content>\n reg numbers compared with girls (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001). Parental atopy history, particularly maternal hay fever and paternal asthma were related to lower\n T<\/jats:styled-content>\n reg numbers in cord blood (adj.\n MR<\/jats:styled-content>\n \u00a0=\u00a00.81, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.68\u20130.97; adj.\n MR<\/jats:styled-content>\n \u00a0=\u00a00.60, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.45\u20130.81). Maternal cytokines (\n IL<\/jats:styled-content>\n \u201013,\n IL<\/jats:styled-content>\n \u201017\n E<\/jats:styled-content>\n and\n IFN<\/jats:styled-content>\n \u2010\u03b3) and maternal smoking\/exposure to tobacco smoke during pregnancy were also associated with decreased cord blood\n T<\/jats:styled-content>\n reg numbers (adj.\n MR<\/jats:styled-content>\n \u00a0=\u00a00.89, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.97\u20131.00). Children with lower\n T<\/jats:styled-content>\n reg numbers at birth had a higher risk to develop atopic dermatitis (adj.\n OR<\/jats:styled-content>\n \u00a0=\u00a01.55, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.00\u20132.41) and sensitization to food allergens (adj.\n OR<\/jats:styled-content>\n \u00a0=\u00a01.55, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.06\u20132.25) during the first year of life.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n These results indicate that both genetic and environmental factors presumably influence the development of foetal\n T<\/jats:styled-content>\n regs. Low cord blood\n T<\/jats:styled-content>\n reg numbers may predict early atopic dermatitis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1398-9995.2011.02767.x","type":"journal-article","created":{"date-parts":[[2011,12,22]],"date-time":"2011-12-22T05:11:42Z","timestamp":1324530702000},"page":"380-389","source":"Crossref","is-referenced-by-count":182,"title":["Cord blood\n T<\/scp>\n regs with stable\n \n FOXP3<\/i>\n <\/scp>\n expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year"],"prefix":"10.1111","volume":"67","author":[{"given":"D.","family":"Hinz","sequence":"first","affiliation":[{"name":"Department of Environmental Immunology UFZ \u2013 Helmholtz Centre for Environmental Research Leipzig Leipzig Germany"},{"name":"Universit\u00e4tsklinikum Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Environmental Immunology UFZ \u2013 Helmholtz Centre for Environmental Research Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"R\u00f6der","sequence":"additional","affiliation":[{"name":"Core Facility Studies UFZ \u2013 Helmholtz Centre for Environmental Research Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Olek","sequence":"additional","affiliation":[{"name":"Epiontis GmbH Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Huehn","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Helmholtz Centre for Infection Research Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Sack","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Borte","sequence":"additional","affiliation":[{"name":"Children's Hospital Municipal Hospital \u201cSt. Georg\u201d Academic Teaching Hospital of the University of Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Simon","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Klinik f\u00fcr Dermatologie, Venerologie und Allergologie Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Environmental Immunology UFZ \u2013 Helmholtz Centre for Environmental Research Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Herberth","sequence":"additional","affiliation":[{"name":"Department of Environmental Immunology UFZ \u2013 Helmholtz Centre for Environmental Research Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the LINA study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00321.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(07)70035-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1800"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940045"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00250.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.04.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02266.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.01.016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19441"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636435"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.10.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737594"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2474"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001783"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2361"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013267"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03434.x"},{"key":"e_1_2_8_19_1","first-page":"300","article-title":"[Reference values for IgE concentration in serum of children. Method: ImmunoCAP\u2010FEIA system]","volume":"140","author":"Liappis N","year":"1992","journal-title":"Monatsschr Kinderheilkd"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7139.1236"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.006"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.01.056"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-40"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.7.587"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01880.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01198.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02587.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703642104"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00290.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00050206"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200901-0135OC"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1245"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.03.025"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2011.02767.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2011.02767.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:44:52Z","timestamp":1695480292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2011.02767.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,22]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1398-9995.2011.02767.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2011.02767.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,22]]}}}