{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:40:04Z","timestamp":1780519204090,"version":"3.54.1"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The identification of disease\u2010eliciting allergens is a prerequisite for accurate prescription of allergen\u2010specific immunotherapy (<jats:styled-content style=\"fixed-case\">SIT<\/jats:styled-content>). The aim of this study was to determine whether molecular diagnosis (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) may change indication and allergen prescription of <jats:styled-content style=\"fixed-case\">SIT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 141 patients with allergic rhinoconjunctivitis and\/or asthma sensitized to pollen with or without concomitant food allergy were included. Skin prick testing with a panel of aeroallergens and a microarray\u2010based panel of allergens (<jats:styled-content style=\"fixed-case\">ISAC<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup>; Phadia, Sweden) was performed in all patients. Prior to learning the results of molecular diagnosis, three of the authors reached a consensus on the indication of <jats:styled-content style=\"fixed-case\">SIT<\/jats:styled-content> and use of allergens following <jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content> recommendations, basing their judgment on clinical history and skin prick test results before and after obtaining the <jats:styled-content style=\"fixed-case\">ISAC<\/jats:styled-content> results. The agreement coefficient (kappa index) was used to analyze the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010nine percent of the patients were women with a mean age of 31\u00a0\u00b1\u00a013.63. Agreement in <jats:styled-content style=\"fixed-case\">SIT<\/jats:styled-content> indication before and after <jats:styled-content style=\"fixed-case\">ISAC<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> results was found in only 62 (46%) patients (kappa\u00a0=\u00a00.1057\u00a0\u00b1\u00a00.0413). Concerning allergens used in the most common prescriptions before and after <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> results, we obtained the following results: \u03ba\u00a0=\u00a00.117\u00a0\u00b1\u00a00.0825 for grass; \u03ba\u00a0=\u00a00.1624\u00a0\u00b1\u00a00.0639 for olive; \u03ba\u00a0=\u00a00.0505\u00a0\u00b1\u00a00.0548 for olive and grass; \u03ba\u00a0=\u00a00.1711\u00a0\u00b1\u00a00.0471 for grass and cypress; \u03ba\u00a0=\u00a00.1897\u00a0\u00b1\u00a00.0493 for grass and London plane; \u03ba\u00a0=\u00a01\u00a0\u00b1\u00a00.0842 for olive and cypress, and \u03ba\u00a0=\u00a00.3586\u00a0\u00b1\u00a00.0798 for other combinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was very low agreement concerning indication and use of allergens for <jats:styled-content style=\"fixed-case\">SIT<\/jats:styled-content> before and after performing <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>. This discrepancy emphasizes the usefulness of <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>, at least in areas of complex sensitization to pollen, in determining correct indication of <jats:styled-content style=\"fixed-case\">SIT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1398-9995.2012.02808.x","type":"journal-article","created":{"date-parts":[[2012,3,3]],"date-time":"2012-03-03T20:42:39Z","timestamp":1330807359000},"page":"709-711","source":"Crossref","is-referenced-by-count":153,"title":["How molecular diagnosis can change allergen\u2010specific immunotherapy prescription in a complex pollen area"],"prefix":"10.1111","volume":"67","author":[{"given":"J.","family":"Sastre","sequence":"first","affiliation":[{"name":"Fundacion Jim\u00e9nez D\u00edaz Allergy Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"},{"name":"CIBER de Enfermedades Respiratorias (CIBERES) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Landivar","sequence":"additional","affiliation":[{"name":"Fundacion Jim\u00e9nez D\u00edaz Allergy Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ruiz\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Fundacion Jim\u00e9nez D\u00edaz Allergy Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Andregnette\u2010Rosigno","sequence":"additional","affiliation":[{"name":"Fundacion Jim\u00e9nez D\u00edaz Allergy Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Mahillo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology ISS Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02474.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70028-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03585.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01219_1.x"},{"issue":"10","key":"e_1_2_9_6_1","first-page":"22","article-title":"Methods for skin testing. EAACI Position paper","volume":"44","author":"Dreborg S","year":"1989","journal-title":"Allergy"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01581.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1398-9995.2006.01078.x","article-title":"The performance of a component\u2010based allergen\u2010microarray in clinical practice","volume":"6","author":"Wohrl S","year":"2006","journal-title":"Allergy"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2012.02808.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2012.02808.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T02:08:16Z","timestamp":1698718096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2012.02808.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,2]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1398-9995.2012.02808.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2012.02808.x","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,2]]}}}