{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:26:02Z","timestamp":1791174362506,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T00:00:00Z","timestamp":1333411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gene variants on chromosome 17q12\u201021 are associated with an increased risk of childhood\u2010onset asthma, a risk known to be modified by environmental tobacco smoke (<jats:styled-content style=\"fixed-case\">ETS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess whether the association of rs2305480 on chromosome 17q12 in the <jats:styled-content style=\"fixed-case\"><jats:italic>GSDML<\/jats:italic><\/jats:styled-content> gene with asthma\u2010like symptoms in the first 4\u00a0years of life is modified by smoke exposure during fetal and early postnatal life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from two independent prospective cohort studies from fetal life onwards in the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etherlands. We genotyped rs2305480 and assessed maternal smoking during pregnancy and <jats:styled-content style=\"fixed-case\">ETS<\/jats:styled-content> exposure at the age of 2. Asthma\u2010like symptoms, defined as any reported wheezing, shortness of breath or dry nocturnal cough, were reported by parents when the children were 1, 2, 3, and 4\u00a0years. Analyses were based on a total group of 4461 <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasian children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> risk\u2010allele of rs2305480 was associated with asthma\u2010like symptoms [overall odds ratio 1.17 (1.11, 1.24), 2.66E\u20109]. The effect of rs2305480 on asthma\u2010like symptoms was stronger among children who were exposed to smoke during fetal life (<jats:italic>P<\/jats:italic>\u2010interaction\u00a0=\u00a00.04). Smoke exposure in early postnatal life was also associated with an increased effect of the 17q12 single nucleotide polymorphism (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) on asthma\u2010like symptoms (<jats:italic>P<\/jats:italic>\u2010interaction\u00a0=\u00a05.06E\u20104). These associations were consistent in both cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A 17q12 variant, rs2305480, was associated with asthma\u2010like symptoms in preschool children, and this association was modified by smoke exposure already during fetal life, and in infancy. Further investigation regarding <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in linkage disequilibrium with rs2305480 in relation to pathophysiological pathways is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1398-9995.2012.02819.x","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T19:19:23Z","timestamp":1333480763000},"page":"767-774","source":"Crossref","is-referenced-by-count":38,"title":["Interaction of a 17q12 variant with both fetal and infant smoke exposure in the development of childhood asthma\u2010like symptoms"],"prefix":"10.1111","volume":"67","author":[{"given":"R. J. P.","family":"van der Valk","sequence":"first","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Pediatrics Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Duijts","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Pediatrics Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kerkhof","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen GRIAC research Institute University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hofman","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A.","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A.","family":"Smit","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht the Netherlands"},{"name":"Centre for Prevention and Health Services Research National Institute for Public Health and the Environment (RIVM) Bilthoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Brunekreef","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht the Netherlands"},{"name":"Division of Environmental Epidemiology Institute for Risk Assessment Sciences Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. S.","family":"Postma","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine and Tuberculosis University Medical Center Groningen GRIAC Research Institute University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. W. V.","family":"Jaddoe","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Pediatrics Erasmus University Medical Center Rotterdam the Netherlands"},{"name":"Department of Epidemiology Erasmus University Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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