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Although there were few economic evaluations and these suffered from methodological shortcomings, the evidence appears to support the cost\u2010effectiveness of immunotherapy as compared with pharmacotherapy for allergic rhinoconjunctivitis, subcutaneous immunotherapy as compared with pharmacotherapy for allergic rhinitis and immunotherapy as compared with pharmacotherapy for allergic rhinitis and asthma. One economic evaluation suggested that immunotherapy as compared with pharmacotherapy is unlikely to be cost\u2010effective for asthma. The questions of the cost\u2010effectiveness of sublingual<jats:italic>vs<\/jats:italic>subcutaneous immunotherapy and of the cost\u2010effectiveness of immunotherapy for allergic conjunctivitis have not been resolved to date. The cost\u2010effectiveness of immunotherapy depends on the duration of the clinical benefit of immunotherapy following treatment cessation, and on the break\u2010even point of cumulative costs between immunotherapy and pharmacotherapy. There is a need for economic evaluations based on high\u2010quality prospective and long\u2010term clinical studies comparing immunotherapy with pharmacotherapy in real\u2010life practice and comparing sublingual with subcutaneous immunotherapy.<\/jats:p>","DOI":"10.1111\/j.1398-9995.2012.02861.x","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T15:53:13Z","timestamp":1341503593000},"page":"1087-1105","source":"Crossref","is-referenced-by-count":30,"title":["The cost\u2010effectiveness of immunotherapy for respiratory allergy: a review"],"prefix":"10.1111","volume":"67","author":[{"given":"S.","family":"Simoens","sequence":"first","affiliation":[{"name":"Research Centre for Pharmaceutical Care and Pharmaco\u2010Economics Leuven 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