{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:27:03Z","timestamp":1772641623961,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T00:00:00Z","timestamp":1341792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Churg\u2013Strauss syndrome (<jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>) and hypereosinophilic syndrome (<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>) overlap considerably in clinical presentation. A reliable means of distinguishing between these groups of patients is needed, especially in the setting of glucocorticoid therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of 276 adult subjects referred for evaluation of eosinophilia &gt;\u00a01500\/\u03bcl was performed, and subjects with a documented secondary cause of eosinophilia or a <jats:italic>\n<jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\n<\/jats:italic>\u2010positive myeloproliferative neoplasm were excluded. The remaining subjects were assessed for the presence of American College of Rheumatology (<jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>) criteria. Laboratory and clinical parameters were compared between subjects with biopsy\u2010proven vasculitis (<jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a08), \u22654 <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> criteria (probable <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a021), <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> with asthma and\/or sinusitis without other <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>\u2010defining criteria (<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>w<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a020), <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> without asthma or sinusitis (<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a018), and normal controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a08). Serum biomarkers reported to be associated with <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> were measured using standard techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences between the subjects with definite or probable <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> with respect to age, gender, or maintenance steroid dose. Serum <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>17, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, and eotaxin levels were significantly increased in eosinophilic subjects as compared to normal controls, but were similar between the eosinophilic groups. Serum <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>17 correlated with eosinophil count (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.73), but not with prednisone dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with a history of asthma and sinusitis, distinguishing between <jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>\u2010negative <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> and <jats:italic>\n<jats:styled-content style=\"fixed-case\">PDGFR<\/jats:styled-content>\n<\/jats:italic>\u2010ne\u2010gative <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> is difficult because of significant overlap in clinical presentation and biomarker profiles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1398-9995.2012.02873.x","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T06:31:11Z","timestamp":1341815471000},"page":"1149-1156","source":"Crossref","is-referenced-by-count":65,"title":["Serum biomarkers are similar in <scp>C<\/scp>hurg\u2013<scp>S<\/scp>trauss syndrome and hypereosinophilic syndrome"],"prefix":"10.1111","volume":"67","author":[{"given":"P.","family":"Khoury","sequence":"first","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Zagallo","sequence":"additional","affiliation":[{"name":"Department of Immunobiology University of Arizona  Tucson AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Talar\u2010Williams","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Dinerman","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health  Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. C.","family":"Holland","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, Clinical Research Directorate\/CMRP SAIC\u2010Frederick, Inc, NCI\u2010Frederick  Frederick MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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