{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:15:59Z","timestamp":1785575759372,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T00:00:00Z","timestamp":1343606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alcohol, exercise or non\u2010steroidal anti\u2010inflamatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>) are frequently mentioned as amplifiers of food allergic reactions but only individual cases or small series have been previously published.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Descriptive study including 74 cases of suspected co\u2010factor enhanced food allergy, assessed by skin\u2010prick tests, specific <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> and oral challenges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anaphylaxis accounted for 85.1% of reactions. In 99% of cases culprit food allergens were plant\u2010derived, mainly vegetables and cereals. <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> were involved in 58%, exercise in 52.7% and alcohol in 12.2%. Lipid transfer protein was the most frequently involved allergen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>o\u2010factor enhanced food allergy should be considered when assessing food, alcohol, exercise and <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> allergic reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1398-9995.2012.02877.x.","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T07:17:02Z","timestamp":1343632622000},"page":"1316-1318","source":"Crossref","is-referenced-by-count":104,"title":["Co\u2010factor\u2010enhanced food allergy"],"prefix":"10.1111","volume":"67","author":[{"given":"V.","family":"Cardona","sequence":"first","affiliation":[{"name":"Allergy Section Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Allergy Research Unit Institut de Recerca Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Luengo","sequence":"additional","affiliation":[{"name":"Allergy Section Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Allergy Research Unit Institut de Recerca Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Garriga","sequence":"additional","affiliation":[{"name":"Allergy Section Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Allergy Research Unit Institut de Recerca Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Labrador\u2010Horrillo","sequence":"additional","affiliation":[{"name":"Allergy Section Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Allergy Research Unit Institut de Recerca Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sala\u2010Cunill","sequence":"additional","affiliation":[{"name":"Allergy Section Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Allergy Research Unit Institut de Recerca Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Allergy Section Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Allergy Research Unit Institut de Recerca Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Soto","sequence":"additional","affiliation":[{"name":"Allergy Section Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Allergy Research Unit Institut de Recerca Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guilarte","sequence":"additional","affiliation":[{"name":"Allergy Section Department of Internal Medicine Hospital Universitari Vall d'Hebron Barcelona Spain"},{"name":"Allergy Research Unit Institut de Recerca Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,30]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.1090b1013e318211496c"},{"key":"e_1_2_4_3_1","first-page":"337","article-title":"A case of food\u2010dependent exercise\u2010induced anaphylaxis due to ingestion of peach","volume":"19","author":"Sato S","year":"2009","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.09-RAI-0125"},{"key":"e_1_2_4_5_1","first-page":"491","article-title":"Pomegranate\u2010dependent exercise\u2010induced anaphylaxis","volume":"18","author":"Gangemi S","year":"2008","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03709.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.C-07-53"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61107-6"},{"key":"e_1_2_4_9_1","first-page":"19","article-title":"Hypersensitivity to lipid transfer protein is frequently associated with chronic urticaria","volume":"43","author":"Asero R","year":"2011","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_4_10_1","first-page":"3","article-title":"Possible interaction among hypersensitivity to lipid transfer proteins, chronic urticaria, and hypersensitivity reactions to nonsteroidal anti\u2010inflammatory drugs","volume":"43","author":"Romano A","year":"2011","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0128-9"},{"issue":"2","key":"e_1_2_4_12_1","first-page":"37","article-title":"Food allergy in Alergologica\u20102005","volume":"19","author":"Fernandez Rivas M","year":"2009","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000265539"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1498"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-1-5"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)80021-4"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.4.506"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.2.571"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-002-0653-x"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1398-9995.2012.02877.x.","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1398-9995.2012.02877.x.","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:42:55Z","timestamp":1695487375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1398-9995.2012.02877.x."}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,30]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1398-9995.2012.02877.x."],"URL":"https:\/\/doi.org\/10.1111\/j.1398-9995.2012.02877.x.","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,30]]}}}