{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:12:59Z","timestamp":1790917979086,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T00:00:00Z","timestamp":1345593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We previously reported that prior nasal administration of highly attenuated <jats:italic>Bordetella pertussis <\/jats:italic><jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1 provides effective and sustained protection against lethal challenge with influenza A viruses. The protective effect was mediated by suppressing the production of major pro\u2010inflammatory mediators. To further explore the anti\u2010inflammatory properties of <jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1, we investigated the effect of <jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1 nasal pretreatment on two mouse models of allergic disease, allergic airway inflammation, and contact hypersensitivity (<jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Allergic reactions were induced in mice nasally pretreated with live attenuated <jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1 bacteria using the ovalbumin (<jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>)\u2010induced allergic airway inflammation and dinitrochlorobenzene (<jats:styled-content style=\"fixed-case\">DNCB<\/jats:styled-content>)\u2010induced <jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content> models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prior <jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1 nasal treatment suppressed <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>\u2010induced lung inflammation and inflammatory cell recruitment and significantly reduced IgE levels and cytokine production. Similarly, <jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1 nasal pretreatment markedly inhibited ear swelling, skin inflammation, and production of pro\u2010inflammatory cytokines in the <jats:styled-content style=\"fixed-case\">DNCB<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content> model. For both models, we showed that <jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1 pretreatment does not affect the sensitization phase. Upon challenge, <jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1 pretreatment selectively reduced the level of cytokines whose production is increased and did not affect the basal level of other cytokines. Together, our observations suggest that <jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1 pretreatment specifically targets those cytokine\u2010producing effector cells that are recruited and involved in the inflammatory reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates the broad anti\u2010inflammatory properties of the attenuated <jats:italic>B. pertussis <\/jats:italic><jats:styled-content style=\"fixed-case\">BPZE<\/jats:styled-content>1 vaccine candidate and supports its development as a promising agent to prevent and\/or treat allergic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1398-9995.2012.02884.x","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T12:13:13Z","timestamp":1345637593000},"page":"1250-1258","source":"Crossref","is-referenced-by-count":21,"title":["Attenuated <i>Bordetella pertussis <\/i><scp>BPZE<\/scp>1 protects against allergic airway inflammation and contact dermatitis in mouse models"],"prefix":"10.1111","volume":"67","author":[{"given":"R.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Microbiology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"},{"name":"Immunology programme Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Immunology programme Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"},{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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