{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:32:54Z","timestamp":1699662774100},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T00:00:00Z","timestamp":1208908800000},"content-version":"vor","delay-in-days":9915,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[1981,3]]},"abstract":"<jats:p>The clinical findings in a 13\u2010year\u2010old 48, XXXY boy are described. His half\u2010sister (same mother) has a 45.X\/XY karyotype. The X<jats:sub>g<\/jats:sub><jats:sup>a<\/jats:sup> blood studies are compatible with his extra X's originating from the mother. These X<jats:sub>g<\/jats:sub><jats:sup>a<\/jats:sup> studies and the IgM levels in the 48, XXXY boy raise the possibility of a gene\u2010dosage effect for X\u2010linked genes affecting these traits. The proband also has chronic pulmonary problems, an interesting association that has been noted with the Klinefelter syndrome, although usually in adults.<\/jats:p>","DOI":"10.1111\/j.1399-0004.1981.tb00693.x","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T01:04:30Z","timestamp":1279501470000},"page":"181-187","source":"Crossref","is-referenced-by-count":1,"title":["An XXXY boy with X\/XY half\u2010sister"],"prefix":"10.1111","volume":"19","author":[{"given":"Michael J.","family":"Welch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Sparkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.230.5.718"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80586-9"},{"key":"e_1_2_1_4_1","first-page":"816","article-title":"Case records of the Massachusetts General Hospital, weekly clinicopathological exercises","volume":"273","author":"Castleman B.","year":"1965","journal-title":"New Engl. 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