{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:24:09Z","timestamp":1757543049667},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T00:00:00Z","timestamp":1208908800000},"content-version":"vor","delay-in-days":9884,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:p>A study of Huntington's Chorea in South Wales has shown a prevalence of 7.61 per 100,000 in the counties of Gwent and Glamorgan, with a total population of 1.7 million. Heterozygote frequency is close to 1 in 5,000. Total ascertainment within this area has been attempted, and experience since conclusion of the study has shown no patients who have been omitted apart from those originating outside the area and those new cases with no living affected relatives. Analysis of migration patterns suggests that around 20 % of cases in each generation arise from outside Glamorgan and Gwent and that around 12 % of first\u2010degree relatives of indigenous cases have left the area. The survey has formed the initial phase of a long\u2010term prospective study of the disease involving systematic genetic counselling of all high\u2010risk individuals and regular surveillance to monitor possible trends in future prevalence.<\/jats:p>","DOI":"10.1111\/j.1399-0004.1981.tb00701.x","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T01:05:28Z","timestamp":1279501528000},"page":"213-221","source":"Crossref","is-referenced-by-count":42,"title":["Huntington's Chorea in South Wales A genetic and epidemiological study"],"prefix":"10.1111","volume":"19","author":[{"given":"D. A.","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E. 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Insan."},{"key":"e_1_2_1_9_1","first-page":"321","article-title":"Genetic variation in Wales","volume":"10","author":"Harper P. S.","year":"1976","journal-title":"J. roy. Coll. Physns."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90356-8"},{"key":"e_1_2_1_11_1","first-page":"295","article-title":"Huntington's chorea in Bedfordshire","volume":"120","author":"Heathfield K. W. G.","year":"1971","journal-title":"Guy's Hospital Reports"},{"key":"e_1_2_1_12_1","unstructured":"HMSO(1973).Registrar General Census: England and Wales. County reports. Part 1 (1971)."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5288.1301"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1192\/bjp.84.348.21","article-title":"Huntington's chorea: a study of 34 families","volume":"84","author":"Minski L.","year":"1938","journal-title":"J. ment. 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