{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T16:23:11Z","timestamp":1698078191408},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T00:00:00Z","timestamp":1208908800000},"content-version":"vor","delay-in-days":8301,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[1985,8]]},"abstract":"<jats:p>Because of the ambiguities in diagnosing carriers of the fragile X syndrome, we studied thirty\u2010six normal females to determine whether the fragile site at Xq27 can be seen in noncarrier females and at what frequency. A fragile site at Xq27 was identified in one out of thirty\u2010six females, occurring at a frequency of 0.5% in her peripheral lymphocytes. We conclude that the fragile Xq27 site occurs only rarely in noncarrier females and that each laboratory should determine its own baseline frequencies of fragile X in order to most accurately distinguish between normal and carrier women.<\/jats:p>","DOI":"10.1111\/j.1399-0004.1985.tb00366.x","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T04:44:27Z","timestamp":1279514667000},"page":"97-99","source":"Crossref","is-referenced-by-count":3,"title":["Frequency of fragile X chromosome in normal females"],"prefix":"10.1111","volume":"28","author":[{"given":"Dunne","family":"Abuelo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Castree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Pueschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresita","family":"Padre\u2010Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Zolnierz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","unstructured":"Blomquist H. K. K. H.Gustavson G.Holmgren F.Nordenson&U.Palsson\u2010Strae(1983).Fragile X syndrome in mildly mentally retarded children in a northern Swedish county. A prevalence study. Clin. Genet.24 393\u2013398.","DOI":"10.1111\/j.1399-0004.1983.tb00092.x"},{"key":"e_1_2_1_3_1","unstructured":"DeArce M.(1983).Table for the cytogenetic study of fragile X chromosomes for diagnostic purposes. Clin. Genet.24 320\u2013323."},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","unstructured":"Herbst D. S. H. G.Dunn F. G.Dill D. K.Kalousek&L. W.Krywaniuk(1981).Further delineation of X\u2010linked mental retardation. Hum. Genet.58 366.","DOI":"10.1007\/BF00282817"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Herbst D. S.&J. R.Miller(1980).Nonspecific X\u2010linked mental retardation II: The frequency in British Columbia. Am. J. Med. Genet.7 461.","DOI":"10.1002\/ajmg.1320070407"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","unstructured":"Jacobs P. A. T. W.Glover M.Mayer P.Fox J. W.Gerrard H. G.Dunn&D. S.Herbst(1980).X\u2010linked mental retardation: A study of seven families. Am. J. Med. Genet.7 471.","DOI":"10.1002\/ajmg.1320070408"},{"key":"e_1_2_1_7_1","unstructured":"Jenkins E. C.Duncan J.Brook K.Lele M.Sanz S.Nolan&T.Brown(1983).Low frequency Fragile X chromosomes in cultures from normal people. American Society of Human Genetics. Proceedings and Abstracts of 34th Annual Meeting; 136A abstract 406.."},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"Lubs H. A. M.Watson R.Breg&F.Lujan(1984).Restudy of the original marker X family. Am. J. Med. Genet.17 133.","DOI":"10.1002\/ajmg.1320170108"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","unstructured":"Mattei M. G. S.Ayme J. F.Mattai Y.Auran&F.Giraud(1979).Distribution of spontaneous chromosome breaks in man. Cytogenet. Cell Genet.23 95.","DOI":"10.1159\/000131309"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","unstructured":"Popovich B. M.Vekemans D.Rosenblatt&P.Monroe(1982).Fragile X. N. Engl. J. Med.306 1551.","DOI":"10.1056\/NEJM198206243062514"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Steinbach P. G.Bardi&H.Boiler(1982).On the frequency of telomeric chromosomal changes induced by culture conditions suitable for fragile X expression. Hum. Genet.61 160.","DOI":"10.1007\/BF00274209"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","unstructured":"Sutherland G. R.(1982).Heritable fragile sites on human chromosomes VIII. Preliminary population cytogenetic data on folic acid sensitive fragile sites. Am. J. Hum. Genet.34 452.","DOI":"10.1007\/BF00282028"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0004.1985.tb00366.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0004.1985.tb00366.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T15:38:49Z","timestamp":1697902729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0004.1985.tb00366.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,8]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,8]]}},"alternative-id":["10.1111\/j.1399-0004.1985.tb00366.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0004.1985.tb00366.x","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,8]]}}}