{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T03:42:47Z","timestamp":1772422967728,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":5963,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:p>Midro AT, Stengel\u2010Rutkowski S, Stene J. Experiences with risk estimates for carriers of chromosomal reciprocal translocations. Clin Genet 1992:41: 113\u2013122.<\/jats:p><jats:p>The risk estimates for individual carriers of ten different familial reciprocal translocations detected among 500 couples with reproductive failures are presented. These were established by application of the empirical data analysed by Stengel\u2010Rutkowski et al. (1988) and the guidelines given in Stene &amp; Stengel\u2010Rutkowski (1988). Different risks were estimated for unbalanced offspring at birth or at second trimester prenatal diagnosis for abortions, or stillbirths\/early deaths. These risk estimates varied considerably from translocation to translocation. Carriers of five translocations had risks for offspring with <jats:italic>single\u2010segment<\/jats:italic> imbalances. The birth risk figures ranged from 0.1% to 13.8%. Carriers of five other translocations had risks for <jats:italic>double\u2010segment<\/jats:italic> imbalances with birth risks ranging from 0% to 3.2%. The estimated risk figures were independent of the method of ascertainment. Among the parents of the index cases we found nine <jats:italic>maternal<\/jats:italic> carriers and only one <jats:italic>paternal<\/jats:italic> carrier. This presentation illustrates the need for individual risk counselling of each carrier with reciprocal translocation regarding further family planning.<\/jats:p>","DOI":"10.1111\/j.1399-0004.1992.tb03646.x","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T07:19:25Z","timestamp":1279523965000},"page":"113-122","source":"Crossref","is-referenced-by-count":46,"title":["Experiences with risk estimates for carriers of chromosomal reciprocal translocations"],"prefix":"10.1111","volume":"41","author":[{"given":"Alina T.","family":"Midro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Stengel\u2010Rutkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Stene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040705"},{"key":"e_1_2_1_3_1","first-page":"197","article-title":"Cytogenetics of human sperm: meiotic segregation in two translocation carriers","volume":"38","author":"Brandriff B.","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00287173"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320330105"},{"key":"e_1_2_1_6_1","first-page":"419","volume-title":"The Cytogenetics of Mammalian Autosomal Rearrangements","author":"Davis JR","year":"1988"},{"key":"e_1_2_1_7_1","volume-title":"Clinical Atlas of Human Chromosomes","author":"Grouchy J.","year":"1984"},{"key":"e_1_2_1_8_1","volume-title":"Cytogenetics and Cell Genetics","author":"ISCN","year":"1985"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112374"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278899"},{"key":"e_1_2_1_11_1","first-page":"221","article-title":"Autosomal translocations and spontaneous abortions","volume":"21","author":"Kowalska\u2010Wochna E.","year":"1980","journal-title":"Genetica Polonica"},{"key":"e_1_2_1_12_1","first-page":"397","volume-title":"The Cytogenetics of Mammalian Autosomal Rearrangements","author":"Martin RH.","year":"1988"},{"key":"e_1_2_1_13_1","unstructured":"MidroAT KorsakE. Czerwinska\u2010CiechanK.Cri\u2010du\u2010chat syndrome in a girl with familial reciprocal translocation t(4;18)(p15.2;q11).1991: In preparation."},{"key":"e_1_2_1_14_1","volume-title":"A Catalogue of Unbalanced Chromosome Aberrations in Man","author":"Schinzel A.","year":"1984"},{"key":"e_1_2_1_15_1","first-page":"3","volume-title":"The cytogenetics of mammalian autosomal rearrangements","author":"Stene J.","year":"1988"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320330106"},{"key":"e_1_2_1_17_1","unstructured":"Stengel\u2010RutkowskiS. SteneJ. GallanoP.Risk Estimates in Balanced Reciprocal Translocations. Analysis of 1120 Pedigrees. Monographie des Annales de G\u00e9n\u00e9tique Expansion Scientifique Fran\u00e7aise Paris 1988. (ISBN: 2\u20137046\u20131248\u2010X)."},{"key":"e_1_2_1_18_1","first-page":"333","article-title":"Case of C\/D chromosomal translocation","volume":"15","author":"Wi\u015bniewski L.","year":"1974","journal-title":"Genetica Polonica"},{"key":"e_1_2_1_19_1","first-page":"443","article-title":"Cytogenetic analysis of fetal tissues from spontaneous abortions","volume":"20","author":"Wi\u015bniewski L.","year":"1979","journal-title":"Genetica Polonica"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0004.1992.tb03646.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0004.1992.tb03646.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T15:04:03Z","timestamp":1698073443000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0004.1992.tb03646.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1111\/j.1399-0004.1992.tb03646.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0004.1992.tb03646.x","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}