{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:12:35Z","timestamp":1763035955121},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T00:00:00Z","timestamp":1093305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p>An ancestral haplotype on chromosome 2p24.1 described in an American sample with familial essential tremor (ET) was analyzed in a different ethnic sample from Singapore. Six polymorphic loci (<jats:italic>etm1240<\/jats:italic>, <jats:italic>etm1231<\/jats:italic>, <jats:italic>etm1234<\/jats:italic>, <jats:italic>APOB<\/jats:italic>, <jats:italic>etm1241<\/jats:italic>, and <jats:italic>etm1242<\/jats:italic>) in a 274\u2010kb interval within an <jats:italic>ET<\/jats:italic> gene candidate region (<jats:italic>ETM2<\/jats:italic>) were analyzed in Singaporean individuals with a family history of ET (n\u2003=\u200352) and compared to Singaporean controls older than age 65 (n\u2003=\u200349). The allele frequencies were significantly different between cases and controls for the loci <jats:italic>etm1234<\/jats:italic> (p\u2003=\u20030.0001) and <jats:italic>APOB<\/jats:italic> (p\u2003=\u20030.0320). An extended haplotype formed by the loci <jats:italic>etm1231<\/jats:italic>, <jats:italic>etm1234<\/jats:italic>, and <jats:italic>APOB<\/jats:italic> occurred with a frequency of 31% in Singaporean cases and in 1.8% of elderly Singaporean controls (p\u2003=\u20030.0005). Haplotype studies in two different population samples suggest that a disease locus for ET lies near or within the 100\u2010kb interval between the loci <jats:italic>etm1231<\/jats:italic> and <jats:italic>APOB<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2004.00306.x","type":"journal-article","created":{"date-parts":[[2004,9,8]],"date-time":"2004-09-08T10:34:04Z","timestamp":1094639644000},"page":"353-357","source":"Crossref","is-referenced-by-count":23,"title":["Haplotype analysis at the <i>ETM2<\/i> locus in a Singaporean sample with familial essential tremor"],"prefix":"10.1111","volume":"66","author":[{"given":"JJ","family":"Higgins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RQ","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EK","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jankovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Pucilowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JP","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000099075.19951.8C"},{"issue":"11","key":"e_1_2_6_3_2","first-page":"S21","article-title":"Essential 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