{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:23:01Z","timestamp":1783596181443,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,7,25]],"date-time":"2005-07-25T00:00:00Z","timestamp":1122249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>Hereditary gingival fibromatosis (HGF) is a rare, benign disorder characterized by slowly progressive fibrous overgrowth of the gingiva. To date, two loci have been mapped in familial cases with autosomal dominant non\u2010syndromic HGF: GINGF (MIM 135300) on chromosome 2p21\u2010p22 and GINGF2 (MIM 605544) on chromosome 5q13\u2010q22. Of the two loci, only <jats:italic>SOS1<\/jats:italic> (<jats:italic>son of sevenless one<\/jats:italic>, MIM 182530) gene underlying GINGF locus has been identified. Ascertainment of a large Chinese family has allowed the mapping of a novel locus to 2p22.3\u2010p23.3, GINGF3. Haplotype construction and analysis localized the new locus to an 11.4\u2010cM interval between markers D2S2221 (telomeric) and D2S1788 (centromeric). The maximum two\u2010point limit of detection (LOD) score of 3.45 (\u03b8\u2003=\u20030) and multipoint LOD score of 5.00 for marker D2S390 strongly supported linkage to this region. Thus, this genetic interval is distal to and does not overlap with the previously described locus, GINGF, on 2p21\u2010p22.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2005.00488.x","type":"journal-article","created":{"date-parts":[[2005,8,11]],"date-time":"2005-08-11T13:05:09Z","timestamp":1123765509000},"page":"239-244","source":"Crossref","is-referenced-by-count":51,"title":["A novel locus for autosomal dominant hereditary gingival fibromatosis, GINGF3, maps to chromosome 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