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The catechol <jats:italic>O<\/jats:italic>\u2010methyltransferase (<jats:italic>COMT<\/jats:italic>) gene maps within the deleted region and is involved in the degradation of dopamine, a neurotransmitter thought to be important in cognition and the development of schizophrenia. Thus, we examined the correlation between neurocognitive deficits and a common polymorphism <jats:italic>Val<\/jats:italic><jats:sup>158<\/jats:sup><jats:italic>Met<\/jats:italic> in the <jats:italic>COMT<\/jats:italic> gene in a cohort of children with 22q11DS. Our results show that children with 22q11DS who have the <jats:italic>Met<\/jats:italic> allele have higher IQ and achievement scores and perform better on measures of prefrontal cognition, such as the Continuous Performance Task, as compared with those with the <jats:italic>Val<\/jats:italic> allele. These results confirm that the hemizygous <jats:italic>COMT Val<\/jats:italic><jats:sup>158<\/jats:sup><jats:italic>Met<\/jats:italic> genotype impacts upon cognition in children with 22q11DS.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2006.00569.x","type":"journal-article","created":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T16:54:26Z","timestamp":1137084866000},"page":"234-238","source":"Crossref","is-referenced-by-count":69,"title":["Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion 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