{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T23:51:00Z","timestamp":1778975460944,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T00:00:00Z","timestamp":1148601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>Studies on Turner syndrome suggested the presence of X\u2010chromosomal\u2010imprinted genes involved in social and verbal cognition. Imprinted genes on autosomes were shown to affect growth. Could imprinting of such genes on the X chromosome also influence psychomotor development and growth in men with Klinefelter syndrome (KS), who have a supernumerary X? We recorded anthropometric and psychomotor development parameters for 61 males with KS (age range 2\u201356\u2003years). In 54 cases, we were able to assess intelligence quotient (IQ) and found that impaired speech \u2013 and motor developmental problems were reported significantly more often in the paternal X \u2013 than in the maternal X group (<jats:italic>P\u2003=<\/jats:italic>\u20030.02). We found some significant (<jats:italic>P\u2003&lt;<\/jats:italic>\u20030.05) increased body size parameters in the paternal X group, which concurs with data reporting a growth promoting influence of paternally derived genes. Our results suggest X\u2010chromosomal imprinting occurs in males with KS.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2006.00635.x","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T14:42:55Z","timestamp":1148654575000},"page":"43-48","source":"Crossref","is-referenced-by-count":51,"title":["Is there an influence of X\u2010chromosomal imprinting on the phenotype in Klinefelter syndrome? A clinical and molecular genetic study of 61 cases"],"prefix":"10.1111","volume":"70","author":[{"given":"D","family":"Stemkens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Roza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Verrij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Swaab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MK","family":"Van Werkhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BZ","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RJ","family":"Sinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JC","family":"Giltay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02517-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg028"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00219178"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/42706"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/35047554"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0250085"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1424"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0432"},{"key":"e_1_2_6_10_2","first-page":"1229","article-title":"Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen\u2010receptor gene correlates with X chromosome inactivation","volume":"51","author":"Allen RC","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/jcem.87.1.8137","article-title":"The androgen receptor CAG repeat polymorphism and X\u2010chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome","volume":"87","author":"Hickey T","year":"2002","journal-title":"J Clin End Metab"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010101)98:1<25::AID-AJMG1015>3.0.CO;2-X"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30058"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000095626.54201.D0"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/341605"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0004.2006.00635.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0004.2006.00635.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:33:21Z","timestamp":1696894401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0004.2006.00635.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,23]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1399-0004.2006.00635.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0004.2006.00635.x","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,23]]}}}