{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:41:23Z","timestamp":1791895283577,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T00:00:00Z","timestamp":1155513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>The BRCAPRO, Couch, Myriad I and II, Ontario Family History Assessment Tool (FHAT), and Manchester models have been used to predict <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation carrier status of women at high risk for developing the heritable form of breast and ovarian cancers. We have evaluated these models for their accuracy in classifying 224 French Canadian families with at least three cases of breast cancer (diagnosed before the age of 65 years), ovarian cancer, or male breast cancer where mutation status was known for an index affected case used to assess the model. This series includes 44 <jats:italic>BRCA1<\/jats:italic> and 52 <jats:italic>BRCA2<\/jats:italic> mutation\u2010positive families. Using receiver operator characteristics analyses, the C\u2010statistics were found to be 0.81, 0.80, 0.79, and 0.74 for the BRCAPRO, FHAT, Manchester, and Myriad II models, respectively, when incorporating both <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> mutation carrier predictions. For the BRCAPRO model, 75% scored greater than a 0.43 probability in the mutation\u2010positive group and 75% scored less than 0.50 in the mutation\u2010negative group. Only 38 of 128 (30%) mutation\u2010negative group had a probability greater than 0.43 with the BRCAPRO model. While all models were highly predictive of carrier status, the BRCAPRO model was the most accurate where a cut\u2010off of 10% would have eliminated 60 of 128 (47%) mutation\u2010negative families for genetic testing and only miss 10 of 96 (10%) mutation\u2010positive families. A review of the cancer phenotypes with high BRCAPRO probabilities showed that significantly more metachronous bilateral breast cancer cases occurred in <jats:italic>BRCA1\/2<\/jats:italic> mutation carrier families in comparison to mutation\u2010negative families, a feature which is not discriminated in the BRCAPRO model.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2006.00673.x","type":"journal-article","created":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T08:13:35Z","timestamp":1155543215000},"page":"320-329","source":"Crossref","is-referenced-by-count":30,"title":["Application of <i>BRCA1<\/i> and <i>BRCA2<\/i> mutation carrier prediction models in breast and\/or ovarian cancer families of French Canadian descent"],"prefix":"10.1111","volume":"70","author":[{"given":"KK","family":"Oros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ghadirian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CM","family":"Maugard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Perret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u2010M","family":"Mes\u2010Masson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WD","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Provencher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PN","family":"Tonin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/302099"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20406"},{"issue":"6","key":"e_1_2_6_4_2","first-page":"1353","article-title":"Screening for mutations in exon 11 of the BRCA1 gene in 70 Italian breast and ovarian cancer patients by protein truncation test","volume":"13","author":"De Benedetti V","year":"1996","journal-title":"Oncogene"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961009)68:2<188::AID-IJC8>3.0.CO;2-U"},{"issue":"3","key":"e_1_2_6_6_2","first-page":"441","article-title":"Founding BRCA1 mutations in hereditary breast and ovarian cancer in southern Sweden","volume":"58","author":"Johannsson O","year":"1996","journal-title":"Am J Hum Genet"},{"issue":"3","key":"e_1_2_6_7_2","first-page":"486","article-title":"Mutations in BRCA1 and BRCA2 in breast cancer families: are there more breast cancer\u2010susceptibility genes?","volume":"60","author":"Serova OM","year":"1997","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200012)16:6<482::AID-HUMU5>3.0.CO;2-O"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00244-1"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20010520)95:3<189::AID-IJC1032>3.0.CO;2-N"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.590606.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.1999.550504.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000053364"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-7-23"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.2.1.69"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2005.00497.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8091231"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362002"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.3.227"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/301670"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.05.121"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550150046034"},{"key":"e_1_2_6_24_2","unstructured":"Myriad.com.Mutation prevalence tables for BRCA1\/2.2004. 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