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The human <jats:italic>LMNA<\/jats:italic> gene was identified in 1986 but it was another 13 years before it was found to be the causative gene for a disease, namely Emery Dreifuss muscular dystrophy. Since then, a further eight clearly defined phenotypes have been associated with <jats:italic>LMNA<\/jats:italic> mutations. The diversity of these phenotypes is striking with features such as premature ageing, axonal neuropathy, lipodystrophy and myopathy being seen. These phenotypes and the emerging genotype\/phenotype correlations are the subject of this review.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2006.00677.x","type":"journal-article","created":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T12:23:12Z","timestamp":1155817392000},"page":"261-274","source":"Crossref","is-referenced-by-count":174,"title":["The laminopathies: a clinical 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