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Recurrent moles account for 2% of all molar cases and a few of them occur in more than one family member. By studying a familial form of recurrent moles, a recessive maternal locus responsible for this condition was mapped to 19q13.4 and causative mutations identified. The defective protein, NALP7, is part of the CATERPILLAR protein family with roles in pathogen\u2010induced inflammation and apoptosis. The exact role of NALP7 in the pathophysiology of molar pregnancies is unknown yet. NALP7 could have a role either in oogenesis or in the endometrium during trophoblast invasion and decidualization. In this review, we outlined recent advances in the field of HMs and reviewed the literature in the light of the new data.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2006.00697.x","type":"journal-article","created":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T13:19:58Z","timestamp":1157548798000},"page":"25-34","source":"Crossref","is-referenced-by-count":63,"title":["The genetics of hydatidiform moles: new lights on an ancient disease"],"prefix":"10.1111","volume":"71","author":[{"given":"R.","family":"Slim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mehio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,6]]},"reference":[{"key":"e_1_2_13_2_2","volume-title":"A collection of cases and observations in midwifery: to illustrate his former treatise, or first volume on that subject","author":"Smellie W","year":"1768"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1939.tb07558.x"},{"key":"e_1_2_13_4_2","first-page":"1665","volume-title":"Ultrasound in obstetrics and gynecology","author":"Bonilla\u2010Musoles F","year":"1993"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb02311.x"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036275"},{"key":"e_1_2_13_7_2","first-page":"1133","volume-title":"Textbook of gynecology","author":"Copeland LJ","year":"1993"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)90370-3"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6934(03)00049-X"},{"issue":"11","key":"e_1_2_13_10_2","first-page":"784","article-title":"Epidemiology of complete molar pregnancy","volume":"29","author":"Craighill MC","year":"1984","journal-title":"J Reprod Med"},{"issue":"3","key":"e_1_2_13_11_2","first-page":"155","article-title":"Advances in the epidemiology of gestational trophoblastic disease","volume":"39","author":"Palmer JR","year":"1994","journal-title":"J Reprod Med"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370010306"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.01413.x"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01245-2"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1982.tb04693.x"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1879-3479.1977.tb00716.x"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(86)90311-2"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.247295.x"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90148-0"},{"issue":"2","key":"e_1_2_13_20_2","first-page":"140","article-title":"Repeat gestational trophoblastic disease","volume":"63","author":"Sand PK","year":"1984","journal-title":"Obstet Gynecol"},{"issue":"1","key":"e_1_2_13_21_2","first-page":"81","article-title":"Gestational trophoblastic disease. 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