{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:04:55Z","timestamp":1792004695576,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,9,2]],"date-time":"2007-09-02T00:00:00Z","timestamp":1188691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>Mitral valve prolapse (MVP) is a very common clinical condition that refers to a systolic billowing of one or both mitral valve leaflets into the left atrium. Improvements of echocardiographic techniques and new insights in mitral valve anatomy and physiology have rendered the diagnosis of this condition more accurate and reliable. MVP can be sporadic or familial, demonstrating autosomal dominant and X\u2010linked inheritance. Three different loci on chromosomes 16, 11 and 13 have been found to be linked to MVP, but no specific gene has been described. Another locus on chromosome X was found to cosegregate with a rare form of MVP called \u2018X\u2010linked myxomatous valvular dystrophy\u2019. MVP is more frequent in patients with connective tissue disorders including Marfan syndrome, Ehlers\u2013Danlos and osteogenesis imperfecta. The purpose of this review is to describe previous studies on the genetics and prevalence of MVP. The report warrants the need for further genetically based studies on this common, albeit not fully understood, clinical entity.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2007.00865.x","type":"journal-article","created":{"date-parts":[[2007,9,7]],"date-time":"2007-09-07T08:41:48Z","timestamp":1189154508000},"page":"288-295","source":"Crossref","is-referenced-by-count":63,"title":["The genetics of mitral valve prolapse"],"prefix":"10.1111","volume":"72","author":[{"given":"JB","family":"Grau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Pirelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u2010J","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AC","family":"Galloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ostrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,2]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907013410101"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02161-7"},{"issue":"131","key":"e_1_2_9_4_2","first-page":"301","article-title":"Nouvelles recherches sur le bruit de galo","volume":"1","author":"Cuffer M","year":"1887","journal-title":"Arch Med Gen Trop"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-189210430-00005"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-190304000-00008"},{"key":"e_1_2_9_7_2","volume-title":"Heart disease","author":"White P","year":"1931"},{"key":"e_1_2_9_8_2","first-page":"353","article-title":"Mid\u2010systolic clicks","volume":"35","author":"Reid JV","year":"1961","journal-title":"S Afr Med J"},{"key":"e_1_2_9_9_2","first-page":"76","article-title":"The significance of late systolic murmurs and mid\u2010late systolic clicks","volume":"12","author":"Barlow JB","year":"1963","journal-title":"Md State Med J"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)90059-6"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.3.589"},{"key":"e_1_2_9_12_2","first-page":"910","volume-title":"Cardiac surgery in the adult","author":"Cohn L","year":"2003"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0146-2806(82)90016-0"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2190451"},{"key":"e_1_2_9_15_2","first-page":"111","article-title":"Fibroelastic dysplasia of the mitral valve. An anatomical and clinical entity","volume":"62","author":"Carpentier A","year":"1980","journal-title":"Circulation"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-4-305"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90204-6"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(87)90956-2"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.3.464"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197605132942004"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90704-4"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90705-6"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80021-8"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430040095032"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90397-6"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.61.3.300"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.52.4.651"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197904053001406"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/352337a0"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1392"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200422715"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(75)90863-2"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90015-5"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.52.6.1091"},{"key":"e_1_2_9_35_2","first-page":"470A","article-title":"Inheritance of the mitral valve prolapse syndrome","volume":"25","author":"Fortuin N","year":"1977","journal-title":"Clin Res"},{"key":"e_1_2_9_36_2","first-page":"111","article-title":"Familial prevalence and genetic transmission of mitral valve prolapse","volume":"54","author":"Scheele W","year":"1976","journal-title":"Circulation"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.35.3.245"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(77)80233-0"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(76)80007-0"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070207"},{"key":"e_1_2_9_41_2","first-page":"1869","article-title":"HLA antigens in mitral valve prolapse","volume":"9","author":"Braun WE","year":"1977","journal-title":"Transplant Proc"},{"key":"e_1_2_9_42_2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1399-0039.1979.tb00847.x","article-title":"The HLA antigens and ABO blood groups in an American black population with mitral valve prolapse","volume":"14","author":"Kaohru R","year":"1979","journal-title":"Tissue Antigens"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1086\/302624"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1086\/375452"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.516930"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.39.5.611"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1086\/301747"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.41.3.279"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.55.6.582"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(79)90042-5"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.38.7.718"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-6-826"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(71)90301-9"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-105-3-384"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.70.5.569"},{"key":"e_1_2_9_56_2","first-page":"511","article-title":"Prevalence of mitral valve prolapse in ethnic groups","volume":"20","author":"Theal M","year":"2004","journal-title":"Can J Cardiol"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0004.2007.00865.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0004.2007.00865.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T19:48:40Z","timestamp":1708199320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0004.2007.00865.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,2]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1399-0004.2007.00865.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0004.2007.00865.x","archive":["Portico"],"relation":{},"ISSN":["0009-9163","1399-0004"],"issn-type":[{"value":"0009-9163","type":"print"},{"value":"1399-0004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,2]]}}}