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Although the deletions did not involve the neurofibromatosis type 1 (NF1) gene, they overlap with long\u2010range deletions of the NF1 region which have been encountered in a small group of NF1 patients with more severe MR. Given the overlap of the deletions in our two patients with the large\u2010sized NF1 microdeletions but not with the more frequent and smaller NF1 deletions, we hypothesize that more than one gene in the 17q11.2q12 region may be involved in MR. We discuss candidate genes for MR within this interval that was precisely defined through array\u2010CGH analysis.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2007.00896.x","type":"journal-article","created":{"date-parts":[[2010,7,19]],"date-time":"2010-07-19T12:01:40Z","timestamp":1279540900000},"page":"411-419","source":"Crossref","is-referenced-by-count":13,"title":["Characterization of <i>de novo <\/i>microdeletions involving 17q11.2q12 identified through chromosomal comparative genomic 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