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A total of 121 adults who had recently been informed of the identification of a family\u2010specific mutation in the <jats:italic>CDKN2A<\/jats:italic> melanoma susceptibility gene, completed a self\u2010report questionnaire assessing cancer\u2010specific and generalized distress, and a variety of potential predictors. Having a personal history of melanoma (OR<jats:italic>\u2003<\/jats:italic>=\u20033.37, p<jats:italic>\u2003<\/jats:italic>=\u20030.033), perceiving greater family implications of melanoma (OR<jats:italic>\u2003<\/jats:italic>=\u20032.52, p\u2003&lt;\u20030.0001), and the tendency to monitor for threatening information (OR<jats:italic>\u2003<\/jats:italic>=\u20033.12, p<jats:italic>\u2003<\/jats:italic>=\u20030.008) were associated with melanoma\u2010specific distress. Being childless (<jats:italic>\u03b2<\/jats:italic>\u2003=\u20032.09, p<jats:italic>\u2003<\/jats:italic>=\u20030.007), perceiving sun exposure as an important cause of melanoma (<jats:italic>\u03b2<\/jats:italic>\u2003=\u20031.15, p<jats:italic>\u2003<\/jats:italic>=\u20030.015), and perceiving greater family implications of melanoma (<jats:italic>\u03b2<\/jats:italic>\u2003=\u20031.02, p<jats:italic>\u2003<\/jats:italic>=\u20030.002) were associated with greater generalized anxiety, while monitoring moderated the relationship between endorsement of a genetic model of melanoma and generalized anxiety (p<jats:italic>\u2003<\/jats:italic>=\u20030.005). As in other common familial cancers, distress was relatively uncommon in this familial melanoma cohort, even after notification of the presence of a family mutation. Participants do not contemplate their melanoma risk in isolation, but evaluate their risk vis\u2010\u00e0\u2010vis the experiences of their relatives.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2007.00949.x","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T10:24:17Z","timestamp":1232706257000},"page":"121-131","source":"Crossref","is-referenced-by-count":20,"title":["Predictors of psychological distress among individuals with a strong family history of malignant 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