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These results have enabled us to narrow the previously proposed critical regions for the craniofacial, urogenital, and neuropsychiatric disease\u2010related manifestations associated with distal 10q deletion syndrome. Furthermore, we propose that haploinsufficiency of the <jats:italic>DOCK1 <\/jats:italic>gene may play a crucial role in the pathogenesis of the 10q deletion syndrome. We hypothesize that alteration of <jats:italic>DOCK1 <\/jats:italic>and\/or other genes involved in regulation and signaling of multiple pathways can explain the wide range of phenotypic variability between patients with similar or identical cytogenetic abnormalities.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2008.01115.x","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T15:35:07Z","timestamp":1245684907000},"page":"54-62","source":"Crossref","is-referenced-by-count":55,"title":["Identification of critical regions for clinical features of distal 10q deletion 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