{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:18:08Z","timestamp":1792718288820,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1499,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1111\/j.1399-0004.2011.01735.x","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T07:12:54Z","timestamp":1308640374000},"page":"226-234","source":"Crossref","is-referenced-by-count":52,"title":["Midline axon guidance and human genetic disorders"],"prefix":"10.1111","volume":"80","author":[{"given":"L","family":"Izzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Charron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,25]]},"reference":[{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1242\/dev.125.5.919","article-title":"Progenitors of dorsal commissural interneurons are defined by MATH1 expression.","volume":"125","author":"Helms","year":"1998","journal-title":"Development"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1242\/dev.01830","article-title":"Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance.","volume":"132","author":"Charron","year":"2005","journal-title":"Development"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0092-8674(94)90421-9","article-title":"Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord.","volume":"78","author":"Kennedy","year":"1994","journal-title":"Cell"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"8866","DOI":"10.1523\/JNEUROSCI.5191-05.2006","article-title":"Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord.","volume":"26","author":"Kennedy","year":"2006","journal-title":"J Neurosci"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0092-8674(00)81336-7","article-title":"Deleted in colorectal cancer (DCC) encodes a netrin receptor.","volume":"87","author":"Keino-Masu","year":"1996","journal-title":"Cell"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/386796a0","article-title":"Phenotype of mice lacking functional deleted in colorectal cancer (Dcc) gene.","volume":"386","author":"Fazeli","year":"1997","journal-title":"Nature"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0092-8674(00)81795-X","article-title":"Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.","volume":"87","author":"Serafini","year":"1996","journal-title":"Cell"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"15642","DOI":"10.1523\/JNEUROSCI.5096-09.2009","article-title":"Netrin-1-dependent spinal interneuron subtypes are required for the formation of left-right alternating locomotor circuitry.","volume":"29","author":"Rabe","year":"2009","journal-title":"J Neurosci"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2008.05.030","article-title":"DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1.","volume":"133","author":"Ly","year":"2008","journal-title":"Cell"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1073\/pnas.0811083106","article-title":"DSCAM functions as a netrin receptor in commissural axon pathfinding.","volume":"106","author":"Liu","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0092-8674(03)00199-5","article-title":"The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance.","volume":"113","author":"Charron","year":"2003","journal-title":"Cell"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature05246","article-title":"Boc is a receptor for sonic hedgehog in the guidance of commissural axons.","volume":"444","author":"Okada","year":"2006","journal-title":"Nature"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuron.2009.03.022","article-title":"Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway.","volume":"62","author":"Yam","year":"2009","journal-title":"Neuron"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1242\/dev.012989","article-title":"BMP type I receptor complexes have distinct activities mediating cell fate and axon guidance decisions","volume":"135","author":"Yamauchi","year":"2008","journal-title":"Development"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0896-6273(00)80827-2","article-title":"BMPs as mediators of roof plate repulsion of commissural neurons.","volume":"24","author":"Augsburger","year":"1999","journal-title":"Neuron"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0896-6273(03)00254-X","article-title":"A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons.","volume":"38","author":"Butler","year":"2003","journal-title":"Neuron"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"a002055.","DOI":"10.1101\/cshperspect.a002055","article-title":"Navigating intermediate targets: the nervous system midline.","volume":"2","author":"Dickson","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.conb.2009.12.006","article-title":"Axon guidance at the midline: of mice and flies.","volume":"20","author":"Evans","year":"2010","journal-title":"Curr Opin Neurobiol"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"a001917.","DOI":"10.1101\/cshperspect.a001917","article-title":"Wiring the brain: the biology of neuronal guidance.","volume":"2","author":"Chedotal","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0896-6273(04)00179-5","article-title":"Conserved roles for Slit and Robo proteins in midline commissural axon guidance.","volume":"42","author":"Long","year":"2004","journal-title":"Neuron"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(04)00303-4","article-title":"The divergent Robo family protein rig-1\/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.","volume":"117","author":"Sabatier","year":"2004","journal-title":"Cell"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0092-8674(00)00041-6","article-title":"Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord.","volume":"102","author":"Zou","year":"2000","journal-title":"Cell"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0896-6273(02)00561-5","article-title":"Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.","volume":"33","author":"Bagri","year":"2002","journal-title":"Neuron"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0896-6273(01)00586-4","article-title":"Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.","volume":"33","author":"Plump","year":"2002","journal-title":"Neuron"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuron.2004.06.018","article-title":"The slit receptor Rig-1\/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons.","volume":"43","author":"Marillat","year":"2004","journal-title":"Neuron"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuron.2008.02.016","article-title":"Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion.","volume":"58","author":"Chen","year":"2008","journal-title":"Neuron"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1399-0004.2004.00354.x","article-title":"Mechanisms regulating the development of the corpus callosum and its agenesis in mouse and human.","volume":"66","author":"Richards","year":"2004","journal-title":"Clin Genet"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"12343","DOI":"10.1523\/JNEUROSCI.6108-08.2009","article-title":"Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons.","volume":"29","author":"Molyneaux","year":"2009","journal-title":"J Neurosci"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"e1000230.","DOI":"10.1371\/journal.pbio.1000230","article-title":"Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.","volume":"7","author":"Niquille","year":"2009","journal-title":"PLoS Biol"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1523\/JNEUROSCI.21-08-02749.2001","article-title":"Cortical axon guidance by the glial wedge during the development of the corpus callosum.","volume":"21","author":"Shu","year":"2001","journal-title":"J Neurosci"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1242\/dev.02379","article-title":"Robo1 regulates the development of major axon tracts and interneuron migration in the forebrain.","volume":"133","author":"Andrews","year":"2006","journal-title":"Development"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1523\/JNEUROSCI.4605-06.2007","article-title":"Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain.","volume":"27","author":"Lopez-Bendito","year":"2007","journal-title":"J Neurosci"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1242\/dev.125.24.5043","article-title":"Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections.","volume":"125","author":"Bagnard","year":"1998","journal-title":"Development"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1242\/dev.124.24.5063","article-title":"A role for netrin-1 in the guidance of cortical efferents.","volume":"124","author":"Metin","year":"1997","journal-title":"Development"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"10346","DOI":"10.1523\/JNEUROSCI.22-23-10346.2002","article-title":"The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons.","volume":"22","author":"Finger","year":"2002","journal-title":"J Neurosci"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"21.","DOI":"10.1186\/1749-8104-3-21","article-title":"Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling.","volume":"3","author":"Faulkner","year":"2008","journal-title":"Neural Dev"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"34.","DOI":"10.1186\/1749-8104-3-34","article-title":"Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.","volume":"3","author":"Runker","year":"2008","journal-title":"Neural Dev"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/mds.22944","article-title":"Developmental and benign movement disorders in childhood.","volume":"25","author":"Bonnet","year":"2010","journal-title":"Mov Disord"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.clinph.2007.11.047","article-title":"Neurophysiology of unimanual motor control and mirror movements.","volume":"119","author":"Cincotta","year":"2008","journal-title":"Clin Neurophysiol"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0304-3940(98)00748-4","article-title":"Differences between \u2018congenital mirror movements' and \u2018associated movements' in normal children: a neurophysiological case study.","volume":"256","author":"Reitz","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1474-4422(05)00990-7","article-title":"Reaching beyond the midline: why are human brains cross wired?","volume":"4","author":"Vulliemoz","year":"2005","journal-title":"Lancet Neurol"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"592.","DOI":"10.1126\/science.1186463","article-title":"Mutations in DCC cause congenital mirror movements.","volume":"328","author":"Srour","year":"2010","journal-title":"Science"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1212\/WNL.0b013e318207b1e0","article-title":"A novel DCC mutation and genetic heterogeneity in congenital mirror movements.","volume":"76","author":"Depienne","year":"2011","journal-title":"Neurology"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"324.","DOI":"10.1136\/jmg.17.4.324","article-title":"Congenital horizontal gaze palsy and kyphoscoliosis.","volume":"17","author":"Dretakis","year":"1980","journal-title":"J Med Genet"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1126\/science.1096437","article-title":"Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis.","volume":"304","author":"Jen","year":"2004","journal-title":"Science"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"e11.","DOI":"10.1136\/jmg.2005.035436","article-title":"Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3.","volume":"43","author":"Chan","year":"2006","journal-title":"J Med Genet"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12031-009-9217-4","article-title":"Allelic ROBO3 heterogeneity in Tunisian patients with horizontal gaze palsy with progressive scoliosis.","volume":"39","author":"Amouri","year":"2009","journal-title":"J Mol Neurosci"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1212\/01.WNL.0000156349.01765.2B","article-title":"Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3.","volume":"64","author":"Bosley","year":"2005","journal-title":"Neurology"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1136\/jnnp.2006.088435","article-title":"Patients with horizontal gaze palsy and progressive scoliosis due to ROBO3 E319K mutation have both uncrossed and crossed central nervous system pathways and perform normally on neuropsychological testing.","volume":"77","author":"Amoiridis","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1212\/01.wnl.0000227960.38262.0c","article-title":"Diffusion tensor MRI shows abnormal brainstem crossing fibers associated with ROBO3 mutations.","volume":"67","author":"Sicotte","year":"2006","journal-title":"Neurology"},{"key":"10.1111\/j.1399-0004.2011.01735.x-BIB51|cit51","doi-asserted-by":"crossref","first-page":"e1000325.","DOI":"10.1371\/journal.pbio.1000325","article-title":"Genetic dissection of the function of hindbrain axonal commissures.","volume":"8","author":"Renier","year":"2010","journal-title":"PLoS Biol"}],"container-title":["Clinical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0004.2011.01735.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1399-0004.2011.01735.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T21:26:59Z","timestamp":1637875619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0004.2011.01735.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,25]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1399-0004.2011.01735.x","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.12406958.13604057","asserted-by":"object"}]},"ISSN":["0009-9163"],"issn-type":[{"value":"0009-9163","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,25]]}}}