{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:10:34Z","timestamp":1700651434247},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T00:00:00Z","timestamp":1366329600000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Genetics"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Rostasy K, Fauth C, Gautsch K, Laimer I, Krabichler B, Wimmer K, Fr\u00fchmesser A, Kotzot D, Moshir S. Modification of risk for cancer as a coincidental finding in DNA array investigation.<\/jats:p><jats:p>The high resolution of modern DNA arrays has the implification of unintended coincidental detection of gene deletions predisposing to late\u2010onset neurological and oncological disorders. Here, we report the case of an 18\u2010year\u2010old girl with mild intellectual disability, facial dysmorphisms, and a microdeletion of approximately 6.3 Mb on 22q12.1q12.3 including <jats:italic>NF2<\/jats:italic>, the gene for neurofibromatosis type 2, and <jats:italic>CHEK2<\/jats:italic>, a modifier gene for breast cancer. Subsequent magnetic resonance imaging of the brain showed she had already developed bilateral vestibular schwannomas. The challenge of DNA arrays and the consequences for genetic counselling and informed consent will be discussed in the light of this unique case with a microdeletion including both a high risk and a moderate risk cancer predisposition gene.<\/jats:p>","DOI":"10.1111\/j.1399-0004.2012.01881.x","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T17:59:41Z","timestamp":1332179981000},"page":"284-287","source":"Crossref","is-referenced-by-count":1,"title":["Modification of risk for cancer as a coincidental finding in DNA array 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CHEK2*1100delC variant acts as a breast cancer risk modifier in non\u2010BRCA1\/BRCA2 multiple\u2010case families","volume":"63","author":"Oldenburg RA","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0416"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.8503"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.064972"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33316"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.045"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000218743"},{"issue":"1","key":"e_1_2_7_17_2","first-page":"35","article-title":"Duplication of the VHL and IRAK2 genes in a patient with mental retardation\/multiple congenital anomalies, epilepsy and ectomorphic habitus","volume":"21","author":"Chabchoub E","year":"2010","journal-title":"Genet 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