{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T21:59:19Z","timestamp":1782338359716,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T00:00:00Z","timestamp":1100044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Nephrotic syndrome occurs rarely after bone marrow transplantation. We describe three patients with myeloid malignancy who developed nephrotic syndrome from 5, 22 and 25\u2003months after allogeneic stem cell transplantation (SCT), confirmed by electron microscopy as membranous glomerulonephritis in two and minimal change glomerulonephritis in one. Proteinuria was initially severe in all and clinically distinct from prior graft\u2010vs.\u2010host disease in two patients. While all responded initially to prednisolone and cyclosporine therapy, two recipients with high\u2010risk leukemia developed late solid organ and bone marrow relapse of their disease, which ultimately proved fatal. The third patient remains alive and disease\u2010free with minimal proteinuria off immunosuppressive therapy. Hence, the onset of <jats:italic>de novo<\/jats:italic> high\u2010grade proteinuria after allogeneic SCT should prompt renal histological confirmation, and a trial of immunosuppressive therapy after other causes of nephritic syndrome have been excluded.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2004.00294.x","type":"journal-article","created":{"date-parts":[[2005,1,13]],"date-time":"2005-01-13T09:46:32Z","timestamp":1105609592000},"page":"141-144","source":"Crossref","is-referenced-by-count":38,"title":["Nephrotic syndrome after stem cell transplantation"],"prefix":"10.1111","volume":"19","author":[{"given":"William S","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J","family":"Nankivell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S","family":"Hertzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,12,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804233381707"},{"key":"e_1_2_7_3_2","first-page":"639","article-title":"Murine chronic graft\u2010versus\u2010host disease as a model for lupus nephritis","volume":"130","author":"Bruijn JA","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701672"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(88)80211-7"},{"key":"e_1_2_7_6_2","first-page":"115","article-title":"Membranous nephropathy with graft\u2010versus\u2010host disease in a bone marrow transplant recipient","volume":"37","author":"Barbara JAJ","year":"1992","journal-title":"Clin Nephrol"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.10.2461"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000185396"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046273"},{"key":"e_1_2_7_10_2","first-page":"357","article-title":"Renal involvement in chronic graft\u2010versus\u2010host disease: a report of two cases","volume":"3","author":"Gomez\u2010Garcia P","year":"1988","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_11_2","first-page":"303","article-title":"Nephrotic syndrome in a bone marrow transplant recipient with chronic graft\u2010versus\u2010host disease","volume":"16","author":"Sato N","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90503-0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000045208"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701527"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000045999"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2000.8304"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNP58231"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2290"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02983805"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0012.2004.00294.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0012.2004.00294.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:07:55Z","timestamp":1696900075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0012.2004.00294.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,2]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1111\/j.1399-0012.2004.00294.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0012.2004.00294.x","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,2]]}}}