{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T22:40:28Z","timestamp":1735944028674,"version":"3.32.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,8,11]],"date-time":"2005-08-11T00:00:00Z","timestamp":1123718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold><jats:bold>Aim:\u2002<\/jats:bold>This study was designed to identify optimal therapeutic sirolimus (SRL) concentrations in black kidney transplant recipients on reduced cyclosporine (CsA) exposure and prednisone.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>Seventy patients (64 living\/six deceased) received CsA (8\u201310\u2003mg\/kg\/d), prednisone, and 15\u2003mg loading dose followed by 5\u2010mg fixed doses of SRL till day 7 when they were randomized to maintain SRL trough concentrations (high\u2010performance liquid chromatography) of 8\u201312 (GI\u2003=\u200334) or 15\u201320 (GII\u2003=\u200336) ng\/mL.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Mean CsA concentrations were 109\u2003\u00b1\u200353 vs. 89\u2003\u00b1\u200341\u2003ng\/mL and 75\u2003\u00b1\u200354 vs. 60\u2003\u00b1\u200335\u2003ng\/mL (ns) at 2 and 6\u2003months. Accordingly, mean SRL trough concentrations were 12.4\u2003\u00b1\u20036.1 vs. 20.0\u2003\u00b1\u20039.5\u2003ng\/mL (p\u2003&lt;\u20030.001) and 10.8\u2003\u00b1\u20035.8 vs. 18.0\u2003\u00b1\u20036.1\u2003ng\/mL (p\u2003&lt;\u20030.001). The incidence of biopsy\u2010proven acute rejection [13% (GI: 18% vs. GII: 8%, ns)], graft loss or death was 16% (GI: 21% vs. GII: 11%, ns]. There were no deaths and three graft losses (GI\u2003=\u20031; GII\u2003=\u20032). Creatinine clearance was higher in GI (64.5\u2003\u00b1\u200317 vs. 54.4\u2003\u00b1\u200314.7\u2003mL\/min, p\u2003=\u20030.011). The incidence of post\u2010transplant diabetes mellitus was 13% and no CMV disease was observed.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>In black recipients of primarily living renal allograft donors reduced CsA exposure and SRL concentration\u2010controlled regimens produced low incidences of acute rejection, post\u2010transplant diabetes mellitus and CMV disease, with no significant impairment in graft function.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2005.00331.x","type":"journal-article","created":{"date-parts":[[2005,9,6]],"date-time":"2005-09-06T09:52:38Z","timestamp":1126000358000},"page":"607-615","source":"Crossref","is-referenced-by-count":12,"title":["Concentration\u2010controlled use of sirolimus associated with reduced exposure of cyclosporine in black recipients of primarily living renal allograft donors: 12\u2010month results"],"prefix":"10.1111","volume":"19","author":[{"given":"Alexandra 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