{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:46:14Z","timestamp":1761630374990},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,6]],"date-time":"2005-05-06T00:00:00Z","timestamp":1115337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Thrombotic microangiopathy (TMA) that occurs after stem cell transplantation (SCT) is generally regarded as being different from thrombotic thrombocytopenic purpura (TTP), because it is reportedly not associated with deficiency of von Willebrand factor\u2010cleaving protease, whereas this enzyme is deficient in TTP. However, better understanding of the pathogenesis of this condition is still required. Accordingly, we investigated the relationship between TMA occurring after SCT and heparin\u2010induced thrombocytopenia (HIT), a condition related to low\u2010dosed heparin therapy that features thrombocytopenia and generalized thrombotic disorders. Thirty\u2010nine consecutive patients who underwent bone marrow transplantation were divided into a TMA group and a non\u2010microangiopathy group (10 and 29 patients, respectively). Before SCT, the serum platelet factor 4 (PF4) levels of the TMA and non\u2010microangiopathy groups were 0.123\u2003\u00b1\u20030.023 and 0.132\u2003\u00b1\u20030.025, respectively (p\u2003=\u2003NS). One week after recovery of the white blood cell count following transplantation, the TMA group (0.2902\u2003\u00b1\u20030.0678) had a significantly higher PF4 level than the non\u2010microangiopathy group (0.1548\u2003\u00b1\u20030.0312) (p\u2003&lt;\u20030.001, <jats:italic>t<\/jats:italic>\u2010test). Thus, PF4 increased after engraftment of the transplanted stem cells in the patients who developed TMA. In patients who developed TMA, there was a significant correlation between the PF4 level and the grade of angiopathy according to the Zeigler grading system (p\u2003&lt;\u20030.01 by linear regression analysis).<\/jats:p><jats:p>These results suggest that a HIT antibody produced by donor cells may be involved in the development of TMA after SCT.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2005.00367.x","type":"journal-article","created":{"date-parts":[[2005,5,6]],"date-time":"2005-05-06T09:35:33Z","timestamp":1115372133000},"page":"418-422","source":"Crossref","is-referenced-by-count":4,"title":["Heparin\u2010induced thrombocytopenia antibody and the pathogenesis of thrombotic microangiopathy after stem cell transplantation"],"prefix":"10.1111","volume":"19","author":[{"given":"Hiroyuki","family":"Takatsuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Wakae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinari","family":"Toda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayuki","family":"Itoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahito","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90106-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1656329"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90134-1"},{"key":"e_1_2_6_5_2","first-page":"495","article-title":"Thrombotic microangiopathy following bone marrow transplantation","volume":"14","author":"Pettitt AR","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_6_2","first-page":"247","article-title":"Bone marrow transplantation\u2010associated thrombotic microangiopathy: a case series","volume":"15","author":"Zeigler ZR","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703710"},{"key":"e_1_2_6_8_2","first-page":"89","article-title":"An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries","author":"Moschowitz E","year":"1924","journal-title":"Arch Intern Med"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.9.3097"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392203"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.11.3798"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.11.2834.bloodjournal79112834"},{"key":"e_1_2_6_13_2","first-page":"3599","article-title":"Incidence and outcome of hepatic veno\u2010occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party","volume":"92","author":"Carreras E","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703342"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0012.2005.00367.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0012.2005.00367.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:22:04Z","timestamp":1696900924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0012.2005.00367.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,6]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1111\/j.1399-0012.2005.00367.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0012.2005.00367.x","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,6]]}}}