{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:24:53Z","timestamp":1776896693022,"version":"3.51.2"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T00:00:00Z","timestamp":1150329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold><jats:bold> Objective:\u2002<\/jats:bold> To observe the efficacy and toxicity of autologous hematopoietic stem cell transplantation (HSCT) in progressive multiple sclerosis (PMS).<\/jats:p><jats:p><jats:bold>Methodology:\u2002<\/jats:bold> Twenty\u2010one patients with PMS were treated with autologous HSCT. Stem cells were mobilized with cyclophosphamide (CY) and granulocyte colony\u2010stimulating factor. After conditioning regimen of CY and total body irradiation or BEAM, stem cells were reinfused. CD34<jats:sup>+<\/jats:sup> cell selection of the graft was performed and anti\u2010thymocyte globulin was given for T\u2010cell depletion. The probabilities of confirmed progression\u2010free survival and disease activity\u2010free survival were used to assess the efficacy and the adverse experiences were recorded to detect the toxicities.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The median follow\u2010up time was 42 (6\u201365)\u2003months. The probabilities of confirmed progression\u2010free survival and the disease activity\u2010free survival were 75% and 33.3%, respectively. The principal adverse events included allergy, infection, elevation of liver enzymes, transient neurologic deterioration and depression. Two patients died of severe pneumonia and varicella\u2010zoster virus hepatitis, at 4.5 and 15\u2003months post\u2010transplant, respectively.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Autologous HSCT seems beneficial to PMS. However, more patients and longer follow up would be required to assess the risk\/benefit ratio.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2006.00510.x","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T15:01:43Z","timestamp":1150383703000},"page":"485-489","source":"Crossref","is-referenced-by-count":55,"title":["Autologous hematopoietic stem cell transplantation for progressive multiple sclerosis: report of efficacy and safety at three yr of follow up in 21 patients"],"prefix":"10.1111","volume":"20","author":[{"given":"Xiu\u2010Shi","family":"Ni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Hui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700944"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-002-0800-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.2.282"},{"key":"e_1_2_6_5_2","first-page":"550","article-title":"A preliminary result of treatment of progressive multiple sclerosis with autologous peripheral blood stem cell transplantation in China","volume":"40","author":"Ouyang J","year":"2001","journal-title":"Chin J Intern Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130302"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.907"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050605"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006682225181"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.04.021"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.04.020"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00966-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3205"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703941"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03728"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4607"},{"key":"e_1_2_6_18_2","first-page":"7","article-title":"Clinical and pathogenic aspects of varicella\u2010zoster","volume":"61","author":"Plotkin SA","year":"1995","journal-title":"Postgrad Med J"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000183272.30570.09"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0012.2006.00510.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0012.2006.00510.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T05:17:21Z","timestamp":1696915041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0012.2006.00510.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1399-0012.2006.00510.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0012.2006.00510.x","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}