{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T05:44:12Z","timestamp":1696916652774},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T00:00:00Z","timestamp":1150156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Kidney transplantation is currently the treatment of choice for end\u2010stage renal disease. Although new immunosuppressive drugs have been introduced into clinical practice, the effect of such medication on quality of life (QoL) in transplant recipients is still unclear. The present study analyzes the impact of tacrolimus\u2010based immunosuppression on QoL in a representative sample of adult kidney transplant recipients from Rio Grande do Sul, a Brazilian southern state. This was a cross\u2010sectional multicenter study which used the SF\u201036 Health Survey for measuring QoL. The effect of tacrolimus on QoL was adjusted for possible confounders using multiple linear regression. A total of 272 patients (from 11 different centers) were evaluated, 48 of them were treated with tacrolimus. Transplant patients in use of tacrolimus presented significant higher scores in the physical component summary of SF\u201036 than non\u2010users (49.1\u2003\u00b1\u20038.3 vs. 46.1\u2003\u00b1\u20038.7; p\u2003=\u20030.03), and such difference was noted in the physical functioning and general health subscales (81.5\u2003\u00b1\u200317.1 and 74.7\u2003\u00b1\u200321.8; 74.6\u2003\u00b1\u200322.3 and 67.1\u2003\u00b1\u200322.3 for users and non\u2010users of tacrolimus, respectively, p\u2003&lt;\u20030.05). The effect of tacrolimus remained significant after adjustment for age, gender, skin color and time since transplantation (coeff.: 2.83; 95% CI: 0.05\u20135.6, p\u2003=\u20030.045). The association between tacrolimus\u2010based immunosuppression and better perception of physical functioning and general health for renal transplant patients represents a significant finding as it may influence therapeutical decisions and contribute to maximize kidney transplantation benefits.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2006.00513.x","type":"journal-article","created":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T11:23:26Z","timestamp":1150197806000},"page":"504-508","source":"Crossref","is-referenced-by-count":8,"title":["Tacrolimus and quality of life after kidney transplantation \u2013 a multicenter study"],"prefix":"10.1111","volume":"20","author":[{"given":"Maristela","family":"Bohlke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Hiss\u00e9","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stela Scaglioni","family":"Marini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisoneide","family":"Terhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin Correa","family":"Barcellos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Curi","family":"Hallal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce","family":"Casarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Claudia","family":"Irigoyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"2000 Annual Report of the US Scientific Registry for Transplant Recipients and the Organ Procurement and Transplantation Network Transplant Data 1990\u20131999","author":"US Department of Health and Human Services, Health Resources and Services Administration"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420901"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011295"},{"key":"e_1_2_5_5_2","first-page":"SS67","article-title":"Improving quality of life: the new target for transplantation","volume":"72","author":"Keown P","year":"2001","journal-title":"Transplantation"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198502283120905"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9669429"},{"key":"e_1_2_5_8_2","first-page":"225","article-title":"Survival trends in long\u2010term first cadaver\u2010donor kidney transplants","volume":"5","author":"Gjertson DW","year":"1991","journal-title":"Clin Transplant"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199512000-00007"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199708150-00012"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91766-3"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199712270-00020"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199812270-00026"},{"key":"e_1_2_5_14_2","first-page":"143","article-title":"Brazilian\u2013Portuguese version of the SF\u201036. A reliable and valid quality of life outcome measure","volume":"39","author":"Ciconelli RM","year":"1999","journal-title":"Rev Bras Reumatol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2002.00071.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000125551.59739.2E"},{"key":"e_1_2_5_17_2","first-page":"3061","article-title":"Quality of life advantages of FK\u2010506 vs conventional immunosuppressive drug therapy in cardiac transplantation","volume":"23","author":"Dew MA","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(97)00461-2"},{"key":"e_1_2_5_19_2","first-page":"3032","article-title":"Changes in quality of life following conversion from CyA to FK 506 in orthotopic liver transplant patients","volume":"23","author":"Felser I","year":"1991","journal-title":"Transplant Proc"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0012.2006.00513.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0012.2006.00513.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T05:17:34Z","timestamp":1696915054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0012.2006.00513.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1399-0012.2006.00513.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0012.2006.00513.x","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}