{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:51:33Z","timestamp":1791229893689,"version":"4.1.0"},"reference-count":85,"publisher":"Wiley","issue":"s17","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Advances in surgical techniques and immunosuppression (IS) have led to an appreciable reduction in postoperative complications following transplantation. However, wound complications as probably the most common type of post\u2010transplantation surgical complication can still limit these improved outcomes and result in prolonged hospitalization, hospital readmission, and reoperation, consequently increasing overall transplant cost. Our aim was to review the literature to delineate the evidence\u2010based risk factors for wound complications following kidney and liver transplantation (KTx, LTx), and to present the preventive and therapeutic modalities for this bothersome morbidity. Generally, wound complications are categorized as superficial and deep wound dehiscences, perigraft fluid collections and seroma, superficial and deep wound infections, cellulitis, lymphocele and wound drainage. The results of several studies showed that the most important risk factors for wound complications are IS and obesity. Additionally, there are surgical and\/or technical factors, including type of incision, reoperation, and surgeon's expertise, as well as comorbidities such as advanced age, diabetes mellitus, malnutrition, and uremia. Preventive management of wound complications necessitates defining their etiological factors so that their detrimental effects on healing processes can be addressed and reduced. IS modalities and agents, especially sirolimus (SRL), and steroids (ST) should be adjusted according to the patient's co\u2010existing risk factors. SRL should be administered three months after transplantation and ST should be tapered as soon as possible. A body mass index (BMI) lower than 30\u2003kg\/m<jats:sup>2<\/jats:sup> is advisable for inclusion in a transplantation program, but higher BMIs do not exclude recipients. Surgical risk factors can be prevented by applying precise surgical techniques. Therapeutic modalities must focus on the most efficient and cost\u2010effective medications and\/or interventions to facilitate and improve wound healing.<\/jats:p>","DOI":"10.1111\/j.1399-0012.2006.00608.x","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T15:45:34Z","timestamp":1162914334000},"page":"97-110","source":"Crossref","is-referenced-by-count":149,"title":["Wound complications following kidney and liver transplantation"],"prefix":"10.1111","volume":"20","author":[{"given":"A.","family":"Mehrabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fonouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Eisenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Encke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.M.","family":"Schmied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Libicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Weitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"B\u00fcchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-003-0384-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2005.00097.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200112270-00009"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1108\/09526869810243935"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)68928-8"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.1999.130203.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2741\/1184"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000093502.26208.42"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50079"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00185.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000123082.31092.53"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000130178.17216.28"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.01.065"},{"key":"e_1_2_6_15_2","first-page":"91","article-title":"Lymphatic cyst seen after radical hysterectomy for cancer of the uterine cervix and its clinical significance","volume":"4","author":"Kobayashi T","year":"1950","journal-title":"Clin Gynec Obstet Tokyo"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000074940.12565.80"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200209270-00012"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35387-9"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199203000-00035"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2005.00137.x"},{"key":"e_1_2_6_21_2","first-page":"249","article-title":"The role of interventional radiology in the management of kidney transplant complications","volume":"110","author":"Carrafiello G","year":"2005","journal-title":"Radiol Med (Torino)"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00244.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41795-2"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(77)90148-0"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1997.01430360061011"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197301000-00010"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000018778"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70634-4"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65843-0"},{"key":"e_1_2_6_30_2","first-page":"277","article-title":"Steroids, retinoids, and wound healing","volume":"11","author":"Anstead GM","year":"1998","journal-title":"Adv Wound Care"},{"key":"e_1_2_6_31_2","first-page":"104","article-title":"Cyclosporine A delays wound healing and apoptosis and suppresses activin beta\u2010A expression in rats","volume":"8","author":"Petri JB","year":"1998","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0658com"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199904150-00017"},{"issue":"3","key":"e_1_2_6_34_2","first-page":"276","article-title":"Adverse effects of sirolimus on wound healing in kidney transplantation","volume":"2","author":"Seaman DS","year":"2002","journal-title":"Am J Transplant"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000072016.13090.4E"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00885.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.12.076"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000121441.76094.6f"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20072"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A128"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000128628.31556.B1"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.116666"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1972.04180090043011"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199002000-00032"},{"key":"e_1_2_6_45_2","first-page":"286","article-title":"Operative risks of obesity","volume":"146","author":"Strauss RJ","year":"1978","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_6_46_2","first-page":"225","article-title":"Incisional infection after colorectal surgery in obese patients","volume":"153","author":"Nystrom PO","year":"1987","journal-title":"Acta Chir Scand"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200209150-00015"},{"key":"e_1_2_6_48_2","first-page":"367","article-title":"Obesity and renal transplantation","volume":"172","author":"Merion RM","year":"1991","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.02.040"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200201150-00009"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-0012.2003.00131.x"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03629.x"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.1999.130111.x"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.10.047"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01124.x"},{"key":"e_1_2_6_56_2","first-page":"191","article-title":"Risk factors of surgical wound infection in patients undergoing herniorrhaphy","volume":"163","author":"Medina M","year":"1997","journal-title":"Eur J Surg"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-55382005000200006"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.26510"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199902270-00002"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.20410.x"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20529"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197512000-00021"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.03.005"},{"key":"e_1_2_6_64_2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/ndt\/10.4.533","article-title":"Deep wound infections in simultaneous pancreas\u2010kidney transplant recipients on peritoneal dialysis","volume":"10","author":"Douzdjian V","year":"1995","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_6_65_2","first-page":"54","article-title":"Inhibition of rapamycin of PDGF\u2010 and bFGF\u2010induced human tenon fibroblast proliferation in vitro","volume":"5","author":"Sala\u2010Prato M","year":"1996","journal-title":"J Glaucoma"},{"key":"e_1_2_6_66_2","first-page":"551","article-title":"Konsensus\u2010statement zu umstellung und therapieoptimierung nierentransplantierter patienten mit sirolimus \u2013 update\u00a02005","author":"Arns W","year":"2005","journal-title":"Nieren- und hochdruckkrankheiten"},{"key":"e_1_2_6_67_2","first-page":"2618","article-title":"Obesity in kidney transplant patients as a risk factor","volume":"25","author":"Blumke M","year":"1993","journal-title":"Transplant Proc"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199559040-00033"},{"issue":"1","key":"e_1_2_6_69_2","first-page":"1047","article-title":"Impact of obesity on renal transplantation","volume":"25","author":"Gill IS","year":"1993","journal-title":"Transplant Proc"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199708270-00009"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00389.x"},{"key":"e_1_2_6_72_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1177\/089686080002000623","article-title":"Is obesity a favourable prognostic factor in peritoneal dialysis patients","volume":"20","author":"Johnson DW","year":"2000","journal-title":"Perit Dial Int"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(00)00703-1"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.04.072"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1998.92102"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004649900956"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(00)00280-5"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00443-8"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00120-003-0299-2"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(88)90028-3"},{"key":"e_1_2_6_81_2","first-page":"2165","article-title":"Surgical complications in renal transplantation","volume":"26","author":"Lai MK","year":"1994","journal-title":"Transplant Proc"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(94)90005-1"},{"key":"e_1_2_6_83_2","first-page":"310","article-title":"Selective decontamination of the digestive tract helps prevent bacterial infections in the early postoperative period after liver transplant","volume":"66","author":"Emre S","year":"1999","journal-title":"Mt Sinai J Med"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-003-8814-5"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2004.04.028"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000184359.76914.b3"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1399-0012.2006.00608.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1399-0012.2006.00608.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T07:45:51Z","timestamp":1695800751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1399-0012.2006.00608.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,7]]},"references-count":85,"journal-issue":{"issue":"s17","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1399-0012.2006.00608.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1399-0012.2006.00608.x","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,7]]}}}